{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:29:25Z","timestamp":1771457365464,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T00:00:00Z","timestamp":1625356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the outcome of men with macroprolactinoma following cabergoline treatment based on tumour size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 94 men, divided into three groups according to adenoma diameter: 10\u201319\u2009mm (Group A, <jats:italic>n<\/jats:italic>\u2009=\u200936); 20\u201339\u2009mm (Group B, <jats:italic>n<\/jats:italic>\u2009=\u200941); or \u226540\u2009mm (Group C, giant prolactinomas, <jats:italic>n<\/jats:italic>\u2009=\u200917). Patients were followed for a mean of 7.5 years with sellar magnetic resonance imaging, visual fields\u00a0and hormone measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean baseline prolactin was 767, 2090 and 24,806\u2009ng\/ml in Groups A, B\u00a0and C, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Prolactin suppression below three times the upper limit of normal\u00a0(ULN) was achieved in 34 (94%; mean weekly cabergoline dose of 1.2\u2009mg), 37 (90%; cabergoline dose, 2.1\u2009mg)\u00a0and 15 (88%; cabergoline dose, 2.8\u2009mg) men (<jats:italic>p<\/jats:italic>\u2009=\u2009.31) in each group. After excluding patients who underwent surgery and radiotherapy, cabergoline suppressed prolactin\u00a0below three times ULN in 32\/35 (91%), 29\/37 (78%)\u00a0and 11\/14 (79%) men in Groups A, B\u00a0and C, respectively (<jats:italic>p<\/jats:italic>\u2009=\u2009.27). Visual deficits were observed in 5 (14%), 12 (29%)\u00a0and 10 (59%) patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01); improvement was achieved in 5\/5 (100%), 11\/12 (92%)\u00a0and 10\/10 (100%) of men in Groups A, B\u00a0and C. Low baseline testosterone was measured in 26 (72%), 39 (95%)\u00a0and 17 (100%) patients in the three groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Following multi\u2010modal treatment, hypogonadism persisted in 3 (8%), 5 (12%)\u00a0and 2 (12%) men, respectively (<jats:italic>p<\/jats:italic>\u2009=\u2009.85).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Macroprolactinomas in men were controlled with cabergoline in 84% of cases, independent of tumour size. Pituitary surgery and adjuvant radiotherapy further improved long\u2010term response to 91%.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14541","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T15:23:12Z","timestamp":1624461792000},"page":"606-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Long\u2010term response to cabergoline and multi\u2010modal treatment in men with macroprolactinoma: Does size really matter?"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3220-6321","authenticated-orcid":false,"given":"Yaron","family":"Rudman","sequence":"first","affiliation":[{"name":"Institute of Endocrinology, Beilinson Hospital Rabin Medical Center  Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadar","family":"Duskin\u2010Bitan","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, Beilinson Hospital Rabin Medical Center  Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yossi","family":"Manisterski","sequence":"additional","affiliation":[{"name":"Maccabi Health Care Services  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barak","family":"Pertzov","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Pulmonary Division, Beilinson Hospital Rabin Medical Center  Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9376-344X","authenticated-orcid":false,"given":"Amit","family":"Akirov","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, Beilinson Hospital Rabin Medical Center  Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiba","family":"Masri\u2010Iraqi","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, Beilinson Hospital Rabin Medical Center  Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9188-3894","authenticated-orcid":false,"given":"Ilan","family":"Shimon","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, Beilinson Hospital Rabin Medical Center  Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03667.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1994.tb02557.x"},{"issue":"7","key":"e_1_2_8_4_1","first-page":"2102","article-title":"Sex\u2010related difference in the growth of prolactinomas: a clinical and proliferation marker study","volume":"82","author":"Delgrange E","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4065\/73.11.1046"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-019-01009-y"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030979"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-67-1-124"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-104-6-777"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1810772"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0912025"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-010-0251-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-014-0563-z"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16052-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1692"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02562.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.9.6798"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.6.6657"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.7.5810"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-18-0682"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-1-33"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-018-1703-4"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0013"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12242"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.7.8645"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-018-0898-y"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2007.10.005"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcs240"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-011-0348-6"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02627.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0897"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01770.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04351.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0791-7"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0752-0741"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-58-6-1188"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40842-015-0006-4"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-17-0933"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1769-8"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-1088-1"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP11324.OR"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-02029-1"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13064"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14541","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T08:58:55Z","timestamp":1693299535000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,4]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/cen.14541"],"URL":"https:\/\/doi.org\/10.1111\/cen.14541","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,4]]},"assertion":[{"value":"2021-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}