{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T16:33:36Z","timestamp":1779381216801,"version":"3.53.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/00749"],"award-info":[{"award-number":["PI17\/00749"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cushing's syndrome (CS) is associated with skeletal muscle structural and functional impairment which may persist long\u2010term despite surgical removal of the source of cortisol excess. Prevalence of sarcopenia and its impact on Health\u2010Related\u2010Quality of Life (HRQoL) in \u2018cured\u2019 CS is not known. There is a need to identify easy biomarkers to help the clinicians recognise patients at elevated risk of suffering sustained muscle function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>We studied 36 women with CS in remission, and 36 controls matched for age, body mass index, menopausal status, and level of physical activity. We analysed the skeletal muscle mass using dual\u2010energy X\u2010ray absorptiometry, muscle fat fraction using two\u2010point Dixon magnetic resonance imaging and muscle performance and strength using the following tests: hand grip strength, gait speed, timed up and go and 30\u2010s chair stand. We assessed HRQoL with the following questionnaires: SarQoL, CushingQoL, SF\u201036. We calculated the sarcopenia index (SI; serum creatinine\/serum cystatin C\u2009\u00d7\u2009100).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prevalence of sarcopenia, according to the European Working Group on Sarcopenia in Older People (EWGSOP), was greater in CS as compared with controls (19% vs. 3%; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Patients with sarcopenia had a lower SarQoL score than those without sarcopenia (61\u2009\u00b1\u200917 vs. 75\u2009\u00b1\u200914; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), and scored worse on the items pain, easy bruising and worries on physical appearance (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05 for all comparisons) of the CushingQoL questionnaire. Patients with sarcopenia had poorer physical functioning on SF\u201036 than those without sarcopenia (60\u2009\u00b1\u200923 vs. 85\u2009\u00b1\u200915; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). SI was lower in patients with sarcopenia than those without (71\u2009\u00b1\u20093 vs. 77\u2009\u00b1\u20092; <jats:italic>p<\/jats:italic>\u2009=\u2009.032), and was associated with intramuscular fatty infiltration, worse performance on the 30\u2010s chair stand test, slower gait speed, and worse muscle weakness\u2010related HRQoL, as measured using the SarQoL questionnaire (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The optimised cut\u2010off value for the SI ratio to diagnose sarcopenia was 72, which yielded a sensitivity of 73% and a specificity of 90%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sarcopenia is common in patients with CS in long\u2010term remission, and associated with impaired quality of life. The SI is a potential biomarker allowing clinicians to identify patients at high risk of muscle dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14568","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T12:05:56Z","timestamp":1627560356000},"page":"735-743","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Prevalence of sarcopenia after remission of hypercortisolism and its impact on HRQoL"],"prefix":"10.1111","volume":"95","author":[{"given":"Luciana","family":"Martel\u2010Duguech","sequence":"first","affiliation":[{"name":"IIB\u2010Sant Pau and Department of Endocrinology\/Medicine Hospital Sant Pau, and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER\u2010ER, Unidad 747), ISCIII Barcelona Spain"},{"name":"Departamento de Medicina Universitat Aut\u00f2noma de Barcelona Barcelona 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