{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:01:39Z","timestamp":1787752899282,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Literature regarding utility of\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010DOTATATE PET\/CT in insulinoma localization across various subgroups [benign\/malignant\/multiple endocrine neoplasia\u20101 (MEN\u20101) syndrome associated] remains scarce. In this study, the performance of\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010DOTATATE PET\/CT was compared with contrast\u2010enhanced computed tomography (CECT) and\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010NODAGA\u2010Exendin\u20104 PET\/CT (whenever available) in an endogenous hyperinsulinemic hypoglycemia (EHH) cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective audit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>\n                      EHH patients [\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200936, lesions (\n                      <jats:italic>n<\/jats:italic>\n                      )\u2009=\u200949, final diagnosis: benign sporadic insulinoma (BSI) (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200920), malignant insulinoma (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20094,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914), MEN\u20101 syndrome associated insulinoma (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20099,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915), Munchausen syndrome (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20092) and drug\u2010induced hypoglycemia (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20091)] having both preoperative imaging modalities (CECT and\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010DOTATATE PET\/CT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Per\u2010lesion sensitivity (Sn) and positive predictive value (PPV) for histopathological diagnosis of insulinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sn and PPV of\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010DOTATATE PET\/CT were 67.3% and 89.2%; 55% and 100%; 85.7% and 100%; and 66.7% and 77% for overall EHH, BSI, malignant, and MEN\u20101 syndrome associated insulinoma cohorts respectively. Despite having comparatively lower sensitivity in BSI cohort,\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010DOTATATE PET\/CT localized a pancreatic tail lesion missed by other modalities.\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010DOTATATE PET\/CT had comparatively higher sensitivity in malignant insulinoma than BSI cohort.\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010DOTATATE PET\/CT also paved the way for successful response to\n                      <jats:sup>177<\/jats:sup>\n                      Lu\u2010based peptide receptor radionuclide therapy (PRRT). In MEN\u20101 cases, lower PPV as compared with BSI was due to uptake in non\u2010insulinoma pancreatic neuroendocrine tumours (Pan\u2010NET).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010DOTATATE PET\/CT has supplemental role in selected cases of BSI with negative and\/or discordant results with CECT and\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010NODAGA\u2010Exendin\u20104 PET\/CT. In malignant insulinoma,\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010DOTATATE\u2010PET\/CT has an additional theranostic potential. Interference due to uptake in non\u2010insulinoma Pan\u2010NET in MEN\u20101 syndrome may hinder insulinoma localization with\n                      <jats:sup>68<\/jats:sup>\n                      Ga\u2010DOTATATE\u2010PET\/CT.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.14586","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:19:58Z","timestamp":1631146798000},"page":"190-199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<sup>68<\/sup>\n                    Ga\u2010DOTATATE PET\/CT imaging in endogenous hyperinsulinemic hypoglycemia: A tertiary endocrine centre experience"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6275-5650","authenticated-orcid":false,"given":"Ravikumar","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Endocrinology Seth GS Medical College &amp; KEM 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