{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:24:17Z","timestamp":1774448657041,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>A nonclassic form of 11\u03b2\u2010hydroxylase deficiency (NC11\u03b2\u2010OHD) has been reported to cause mild androgen excess symptoms. Currently, the gold standard for biochemical diagnosis is elevated 11\u2010deoxycortisol (11\u2010DOC) levels after corticotropin stimulation test (ACTHstimT). However, there are no clear 11\u2010DOC level cutoffs. One of the accepted references for 11\u2010DOC levels for the paediatric population was published in 1991 by Lashansky et al.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the correlation between 11\u2010DOC levels measured during ACTHstimT and clinical symptoms attributed to NC11\u03b2\u2010OHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective study including all paediatric patients who underwent ACTHstimT at Shamir Medical Center between 2007 and 2015. Clinical data were collected from the patients\u2019 medical files. Outcome measures included the number of patients with hyperandrogenism signs and predefined elevated 11\u2010DOC cut\u2010off levels according to Lashansky for sex and age, and according to commercial kit cut\u2010offs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were complete at presentation for 136 patients. Long\u2010term clinical data were documented for 98 patients, mean follow\u2010up duration of 3.1 years (1.37\u20135.09). There was no statistically significant difference in the number of cases with elevated 11\u2010DOC according to both cut\u2010offs and early puberty, premature adrenarche nor acne. Follow\u2010up data demonstrated no statistically significant difference in the number of cases with elevated 11\u2010DOC levels among patients with compromised final adult height, polycystic ovarian syndrome or hyperandrogenism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Basal and corticotropin stimulated 11\u2010DOC levels were not significantly elevated above the 1.5 times cut\u2010offs according to paediatric\u2010specific norms or the commercial assay\u00a0in paediatric individuals with possible clinical suspicion of NC11\u03b2\u2010OHD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14597","type":"journal-article","created":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T00:21:26Z","timestamp":1633134086000},"page":"302-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Are current cut\u2010off values of 11\u2010DOC in children useful for assessing suspected nonclassical 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