{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:21:03Z","timestamp":1783488063777,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Type 2 diabetes mellitus (T2DM) and hypertension commonly coexist; however,\u00a0underlying primary aldosteronism (PA) can lead to worsening of hypertension, glycemia and cardiovascular risk. We aim to screen patients with T2DM and hypertension for PA by conducting a prospective monocentric study from Western India, which included adults with T2DM and hypertension from the outpatient diabetes clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Measurements<\/jats:title>\n                    <jats:p>Patients with an aldosterone renin ratio of \u22651.6\u2009ng\/dl\/\u00b5IU\/ml with plasma aldosterone concentration (PAC)\u2009\u2265\u200910\u2009ng\/dl were considered to be positive on a screening test. A PAC\u2009\u2265\u20096\u2009ng\/dl on seated saline suppression test (SST) was used to confirm the diagnosis of PA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four hundred and eighty\u2010six patients were included in this\u00a0study. Seventy\u2010six (15.6%, 95% confidence interval [CI]: 12.7%\u201319.1%) patients had a positive screening test with positive confirmatory test in 20 of the 36 (55.5%, 95% CI: 39.3%\u201371.7%) screen\u2010positive patients who underwent SST. Patients with positive screening test had a higher proportion of females (65.8% vs. 50%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.011), frequent history of hypertensive crises (21.1% vs. 8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001), uncontrolled blood pressure (51.3% vs. 34.6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.006), diagnosis of hypertension before diabetes (32.9% vs. 21.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.035) and higher systolic (137.6\u2009\u00b1\u20096.9 vs. 131.2\u2009\u00b1\u200917.8\u2009mmHg;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.004) and diastolic (85.3\u2009\u00b1\u200911.1 vs. 81.7\u2009\u00b1\u200910.7\u2009mmHg;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.007) blood pressures. Patients with positive confirmatory test had longer duration of diabetes (108 [60\u2013162] vs. 42 [24\u201387] months;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.012), hypertension (84 [42\u2013153] vs. 36 [15\u201381] months;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.038) and higher creatinine (1.16 [1.02\u20131.42] vs. 0.95 [0.84\u20131.12]\u2009mg\/dl;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.021).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PA is prevalent (at least 4.1%) in Asian Indian patients with T2DM and hypertension. Further studies are needed to assess the cost\u2010effectiveness of routine screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.14598","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T02:33:06Z","timestamp":1632796386000},"page":"539-548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prevalence of primary aldosteronism in type 2 diabetes mellitus and hypertension: A prospective study from Western India"],"prefix":"10.1111","volume":"96","author":[{"given":"Saba S.","family":"Memon","sequence":"first","affiliation":[{"name":"Department of Endocrinology Seth G S Medical College and KEM Hospital Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9623-4471","authenticated-orcid":false,"given":"Anurag","family":"Lila","sequence":"additional","affiliation":[{"name":"Department of 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