{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T21:12:57Z","timestamp":1766869977282,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Neurosecretory dysfunction (NSD) causes growth hormone deficiency (GHD). Data on adult height after recombinant human growth hormone (rhGH) treatment are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Patients<\/jats:title><jats:p>We collected treatment data of all patients with NSD seen between 1990 and 2017 at our outpatient department (tertiary centre) and measured adult height. For comparison, patients with idiopathic GHD were used. Diagnoses were based on short stature (&lt;\u22122 standard deviation score [SDS]), continuously low height velocity (&lt;25th percentile), delayed bone age (by &gt;1\u2009SD) and low serum IGF\u20101 concentration (&lt;\u22122 SDS). NSD was defined by normal GH challenge results, but subnormal spontaneous GH secretion. Exclusion criteria were no information on adult height, underweight and other short stature disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 67 patients diagnosed with NSD, six were still growing, 31 had test results exceeding validated GH cut\u2010offs and three had other disorders causing short stature. Out of the 25 eligible patients with NSD, 21 could be recruited. These patients reached an adult height of \u22120.85 SDS (mean); 0.34 SDS below midparental height. Height gain during treatment was 2.01 SDS. This outcome was not different to 32 patients with idiopathic GHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term results suggest the viability of the diagnosis of NSD and the efficacy of rhGH treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14608","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T08:59:59Z","timestamp":1634288399000},"page":"184-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Adult height after treatment of neurosecretory dysfunction and comparison to idiopathic GHD"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7988-3587","authenticated-orcid":false,"given":"Gerhard","family":"Binder","sequence":"first","affiliation":[{"name":"University\u2010Children's Hospital T\u00fcbingen, Pediatric Endocrinology  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"H\u00e4hnel","sequence":"additional","affiliation":[{"name":"University\u2010Children's Hospital T\u00fcbingen, Pediatric Endocrinology  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Weber","sequence":"additional","affiliation":[{"name":"University\u2010Children's Hospital T\u00fcbingen, Pediatric Endocrinology  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Schweizer","sequence":"additional","affiliation":[{"name":"University\u2010Children's Hospital T\u00fcbingen, Pediatric Endocrinology  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1984.03340410031028"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000452150"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000181869"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000181592"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01773.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-32-3-356"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-5-1127"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-72-3-647"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-1-230"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2011.05.007"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.584906"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000503783"},{"issue":"11","key":"e_1_2_8_14_1","first-page":"1257","article-title":"Basal characteristics and first year responses to human growth hormone (GH) vary according to diagnostic criteria in children with non\u2010acquired GH deficiency (naGHD): observations from a single center over a period of five decades","volume":"31","author":"Ranke MB","year":"2018","journal-title":"J Pediatr Endocrinol Metab"},{"key":"e_1_2_8_15_1","unstructured":"German guideline.https:\/\/www.awmf.org\/leitlinien\/detail\/ll\/174-002.html"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2011.201"},{"issue":"6","key":"e_1_2_8_17_1","first-page":"1610","article-title":"Serum levels of insulin\u2010like growth factor I (IGF\u2010I) and IGF binding protein 3 reflect spontaneous growth hormone secretion","volume":"76","author":"Blum WF","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_8_18_1","first-page":"1","article-title":"Physical growth of Swiss children from birth to 20 years of age. 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