{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:04:54Z","timestamp":1756994694516,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the impact of indices of adrenal venous sampling (AVS) on postsurgical outcomes in patients with primary aldosteronism (PA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Patients<\/jats:title><jats:p>This retrospective study determined biochemical and clinical outcomes based on ACTH\u2010stimulated AVS parameters (lateralisation index [LI], contralateral ratio [CLR], and ipsilateral ratio [ILR]) in 251 patients with PA at 3 months after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Modified complete biochemical success was achieved in 8 of 12 (66.7%) patients with LI\u2009=\u20093\u20134, 39 of 47 (83.0%) with LI\u2009=\u20094\u201310, and 155 of 169 (91.7%) with LI\u2009\u2265\u200910 (<jats:italic>p<\/jats:italic>\u2009=\u2009.004 for trend). Modified complete biochemical success was achieved in 29 of 38 (76.3%) patients with CLR\u2009\u2265\u20091 and ILR\u2009\u2264\u20092, 73 of 86 (84.9%) with CLR\u2009=\u20090.25\u20131 and ILR\u2009&gt;\u20092, and 100 of 104 (96.2%) with CLR\u2009&lt;\u20090.25 and ILR\u2009&gt;\u20092 (<jats:italic>p<\/jats:italic>\u2009=\u2009.001 for trend). After adjusting for confounders, modified complete biochemical success was associated with an LI\u2009\u2265\u200910 (odds ratio [OR]\u2009=\u20096.32; 95% confidence interval [CI]\u2009=\u20091.33\u201329.93) using LI\u2009=\u20093\u20134 as a reference and combined CLR\u2009&lt;\u20090.25 and ILR\u2009&gt;\u20092 (OR\u2009=\u200911.49; 95% confidence interval [CI]\u2009=\u20092.49\u201353.01) using combined CLR\u2009\u2265\u20091 and ILR\u2009\u2264\u20092 as a reference. Using combined CLR\u2009\u2265\u20091 and ILR\u2009\u2264\u20092 as a reference, complete clinical success was associated with combined CLR\u2009&lt;\u20090.25 and ILR\u2009&gt;\u20092 (OR\u2009=\u20093.10; 95% CI\u2009=\u20091.03\u20139.28) and combined CLR\u2009=\u20090.25\u20131 and ILR\u2009&gt;\u20092 (OR\u2009=\u20094.92; 95% CI\u2009=\u20091.64\u201314.76).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LI\u2009\u2265\u200910 may be appropriate for achieving biochemical success. With ILR\u2009&gt;\u20092, CLR\u2009&lt;\u20090.25, and CLR\u2009&lt;\u20091 may be appropriate for achieving biochemical and clinical success, respectively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14610","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T16:29:52Z","timestamp":1634488192000},"page":"521-530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Indices of ACTH\u2010stimulated adrenal venous sampling as predictors of postsurgical outcomes in primary aldosteronism"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0496-247X","authenticated-orcid":false,"given":"Seung Hun","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of 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Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Seoul National University Hospital and College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery Seoul National University Hospital and College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8183-2604","authenticated-orcid":false,"given":"Yu\u2010Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae\u2010Yon","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of 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