{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:35:59Z","timestamp":1783978559469,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>People who are severely obese due to melanocortin\u20104 receptor (MC4R) deficiency experience hyperphagia and impaired fullness after a meal (satiety). Meal\u2010induced satiety is influenced by hormones, such as peptide\u2010YY (PYY), which are released by enteroendocrine cells upon nutrient delivery to the small intestine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>We investigated whether gastric emptying and PYY levels are altered in MC4R deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Gastric emptying was measured with a gastric scintigraphy protocol using technetium\u201099m (<jats:sup>99<\/jats:sup>Tc<jats:sup>m<\/jats:sup>)\u2010Tin Colloid for 3.5\u2009h in individuals with loss of function <jats:italic>MC4R<\/jats:italic> variants and a control group of similar age and weight. In a separate study, we measured plasma PYY levels before and at multiple time points after three standardised meals given to individuals with MC4R deficiency and controls. Fasting PYY (basal secretion) and postprandial PYY levels were measured and the area under the curve and inter\u2010meal peak were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that gastric emptying time was significantly delayed and percentage meal retention increased in individuals with MC4R deficiency compared to obese controls. In addition, fasting and mean PYY secretion throughout the day were decreased in MC4R deficiency, whereas postprandial PYY secretion was unaltered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Delayed gastric emptying and reduced basal PYY secretion may contribute to impaired satiety in people with obesity due to MC4R deficiency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14615","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T11:54:37Z","timestamp":1635162877000},"page":"270-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with delayed gastric emptying"],"prefix":"10.1111","volume":"96","author":[{"given":"Eleonora","family":"Seelig","sequence":"first","affiliation":[{"name":"Wellcome Trust\u2010MRC Institute of Metabolic Science, Addenbrooke's Hospital University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre Hills Road Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elana","family":"Henning","sequence":"additional","affiliation":[{"name":"Wellcome Trust\u2010MRC Institute of Metabolic Science, Addenbrooke's Hospital University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre Hills Road Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia M.","family":"Keogh","sequence":"additional","affiliation":[{"name":"Wellcome Trust\u2010MRC Institute of Metabolic Science, Addenbrooke's Hospital University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre Hills Road Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9773-6502","authenticated-orcid":false,"given":"Daniel","family":"Gillett","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Addenbrooke's Hospital  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Addenbrooke's Hospital  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Buscombe","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Addenbrooke's Hospital  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6971-8828","authenticated-orcid":false,"given":"Agatha A.","family":"van der Klaauw","sequence":"additional","affiliation":[{"name":"Wellcome Trust\u2010MRC Institute of Metabolic Science, Addenbrooke's Hospital University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre Hills Road Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7609-3504","authenticated-orcid":false,"given":"I. Sadaf","family":"Farooqi","sequence":"additional","affiliation":[{"name":"Wellcome Trust\u2010MRC Institute of Metabolic Science, Addenbrooke's Hospital University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre Hills Road Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81865-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022050"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0153"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5335.135"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22221"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0780-13.2013"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12263-014-0384-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.10.004"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00887"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06212"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.09.010"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.107.048116"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2607"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2011.11.001"},{"issue":"1","key":"e_1_2_7_16_1","first-page":"5","article-title":"Predicting basal metabolic rate, new standards and review of previous work","volume":"39","author":"Schofield WN","year":"1985","journal-title":"Hum Nutr Clin Nutr"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c130055"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0803085"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2297"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0038-z"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-05522-9"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0972"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065696"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14615","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14615","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:45:17Z","timestamp":1693197917000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,25]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/cen.14615"],"URL":"https:\/\/doi.org\/10.1111\/cen.14615","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,25]]},"assertion":[{"value":"2021-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}