{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:18:05Z","timestamp":1789010285287,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Polyuria\u2010polydipsia syndrome (PPS) is a common presentation in children but the differential diagnosis rests on burdensome water deprivation tests. The aims of this study were to determine a copeptin threshold to distinguish patients with central diabetes insipidus from those with primary polydipsia and to estimate the normal range of copeptin concentrations in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Single\u2010centre retrospective descriptive study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Two hundred and seventy\u2010eight children aged 2 months to 18 years who consulted for PPS (<jats:italic>N<\/jats:italic>\u2009=\u200940) or other reasons (control group, <jats:italic>N<\/jats:italic>\u2009=\u2009238) at La Timone University Hospital in Marseille, France, between April 2015 and September 2019 and had a copeptin assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Ultrasensitive copeptin assays on blood samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the children with PPS, the mean copeptin concentrations were 1.72, 55.2 and 15.7\u2009pmol\/l in those with central diabetes insipidus (<jats:italic>N<\/jats:italic>\u2009=\u200921), nephrogenic diabetes insipidus (<jats:italic>N<\/jats:italic>\u2009=\u20093), and primary polydipsia (<jats:italic>N<\/jats:italic>\u2009=\u200916), respectively. Copeptin levels lower than 3.53\u2009pmol\/l were diagnostic of central diabetes insipidus with 100% sensitivity and 87.4% specificity (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The 5th\u201395th copeptin percentile range in the control group was 2.53\u201321.03\u2009pmol\/L. Copeptin levels were significantly higher in boys than in girls but there was no association with age, pubertal stage, body mass index, or the reason for consulting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate copeptin assays may be valuable in the differential diagnosis of PPS in children. Larger prospective studies are required to establish their accuracy in everyday clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14620","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T11:48:39Z","timestamp":1635162519000},"page":"47-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Copeptin assays in children for the differential diagnosis of polyuria\u2010polydipsia syndrome and reference levels in hospitalized children"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5257-2594","authenticated-orcid":false,"given":"Laura","family":"Bonnet","sequence":"first","affiliation":[{"name":"Department of Pediatrics, APHM, INSERM, MMG, H\u00f4pital la Timone Enfants Aix Marseille Univ Marseille 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