{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:41:51Z","timestamp":1791906111850,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Rathke's cleft cysts are benign, embryological remnants in the pituitary gland. The majority of them are small and asymptomatic but a few may become large, and cause mass effects, pituitary hormone deficiencies and visual impairment. Recommendations for the follow\u2010up of Rathke's cleft cysts vary since data on the natural history are sparse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Design<\/jats:title>\n                    <jats:p>Data at diagnosis and at 1, 5 and 10 years for patients with a Rathke's cleft cyst (434 at diagnosis, 317 females) were retrieved from the Swedish Pituitary Registry. Cysts \u22643\u2009mm in diameter were excluded from the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Data included demographics, cyst size, pituitary function, visual defects and surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age at diagnosis was 45 years. In patients with cysts &lt;10\u2009mm in diameter (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009204) 2.9% had pituitary hormone deficiencies and 2% had visual field impairments. Cyst size did not progress during the 5 years. Cysts with a diameter of \u226510\u2009mm that were not operated (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009174) decreased in size over the years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01). Pituitary hormone deficiencies and visual impairments were more frequent (18% and 5.7%, respectively) but were stable over time. Transphenoidal surgery was performed in 56 patients of whom 51 underwent surgery before the 1\u2010year follow\u2010up. The mean cyst diameter at diagnosis was 18\u2009mm (range: 9\u250030\u2009mm), 36% had pituitary hormone deficiency, 45% had visual field defects and 20% had impaired visual acuity. One year after surgery 60% had no cyst remnants, 50% had a pituitary deficiency, 26% had visual field defects and 12% had impaired visual acuity. No major changes were observed after 5 years. Twelve of the operated patients had a follow\u2010up at 10 years, in eight the cyst remnants or recurrences increased in size over time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Rathke's cleft cysts with a size less than 10\u2009mm rarely grow and our results indicate that radiological follow\u2010up can be restricted to 5 years. In contrast, progression of postoperative remnants or recurrent cysts is more likely and require long\u2010term follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.14622","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T10:56:33Z","timestamp":1635764193000},"page":"54-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Natural history and surgical outcome of Rathke's cleft cysts\u2014A study from the Swedish Pituitary Registry"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2970-8593","authenticated-orcid":false,"given":"Maria","family":"Petersson","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet and Department of Endocrinology Karolinska University Hospital Stockholm 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Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8732-7361","authenticated-orcid":false,"given":"Bertil","family":"Ekman","sequence":"additional","affiliation":[{"name":"Department of Endocrinology in Link\u00f6ping and Department of Health, Medicine and Caring Sciences Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"Wahlberg","sequence":"additional","affiliation":[{"name":"Department of Endocrinology in Link\u00f6ping and Department of Health, Medicine and Caring Sciences Link\u00f6ping University Link\u00f6ping Sweden"},{"name":"Department of Internal Medicine, School of Health and Medical Sciences \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Burman","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sk\u00e5ne University Hospital University of Lund Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Borg","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sk\u00e5ne University Hospital University of Lund Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Siesj\u00f6","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sk\u00e5ne University Hospital University of Lund Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6471-9503","authenticated-orcid":false,"given":"Per","family":"Dahlqvist","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Karin","family":"\u00c5kerman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Health and 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