{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:21:40Z","timestamp":1740126100125,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM201511007"],"award-info":[{"award-number":["SZSM201511007"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673201"],"award-info":[{"award-number":["81673201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the association between obesity and precocious puberty from the perspective of genetic polymorphism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Two hundred and ninety\u2010eight pairs of girls in early puberty and age\u2010matched controls (\u00b13 months) were recruited. The genotypes of four obesity\u2010related single\u2010nucleotide polymorphism (SNP) loci (rs10968576, rs12935153, rs4674340 and rs7635103) were determined and the effect of variation on early puberty in Chinese Han girls was evaluated. The unstimulated luteinizing hormone (LH), follicle\u2010stimulating hormone and estradiol levels were also measured to determine the relationship with SNP polymorphisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The effect allele A of rs12935153 was associated with early puberty (odds ratio [OR]\u2009=\u20091.256, 95% confidence interval [CI]: 1.010\u20131.585), but the significance disappeared after multiple comparisons. After adjusting for body mass index, rs12935153 variation increased the risk of early puberty in additive (OR\u2009=\u20091.589, 95% CI: 1.222\u20132.066), dominant (OR\u2009=\u20091.788, 95% CI: 1.210\u20132.642) and recessive (OR\u2009=\u20091.915, 95% CI: 1.207\u20133.038) models of inheritance. Individuals harbouring AA genotype in rs12935153 had a risk of higher LH levels than that of wild type (OR\u2009=\u20091.668, 95% CI: 1.093\u20132.546).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The association between obesity and precocity can be explained from a genetic perspective. Our study suggests that variations in rs12935153 increase the risk of early puberty in Chinese girls. Further studies are needed to verify our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14631","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T06:13:01Z","timestamp":1636611181000},"page":"319-327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Obesity\u2010related genetic polymorphisms are associated with the risk of early puberty in Han Chinese girls"],"prefix":"10.1111","volume":"96","author":[{"given":"Di","family":"Li","sequence":"first","affiliation":[{"name":"Department of School Hygiene Shenzhen Center for Disease Control and Prevention Shenzhen Guangdong China"},{"name":"Department of Clinical Nutrition, Shenzhen University General Hospital Shenzhen University Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boxian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of School Hygiene Shenzhen Center for Disease Control and Prevention Shenzhen Guangdong China"},{"name":"Medical department, Hospital of Stomatology SunYat\u2010sen University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinquan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of School Hygiene Shenzhen Center for Disease Control and Prevention Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of School Hygiene Shenzhen Center for Disease Control and Prevention Shenzhen Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of School Hygiene Shenzhen Center for Disease Control and Prevention Shenzhen Guangdong 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