{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:59:31Z","timestamp":1761897571798,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","award":["4105\u201000008B"],"award-info":[{"award-number":["4105\u201000008B"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The importance of calcium intake from dairy in regard to cardiovascular health has been investigated in several studies with discrepant results. Hence, we aim to investigate the immediate effects of milk intake on cardiovascular function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A randomized crossover study with at least 10 days for washout between the two interventions, 500\u2009ml of water with 200\u2009\u00b5g of cholecalciferol or 500\u2009ml of semi\u2010skimmed milk containing approximately 600\u2009mg of calcium with 200\u2009\u00b5g of cholecalciferol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Twenty community\u2010based postmenopausal women aged 60\u201380 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Parathyroid hormone and ionized calcium were measured at baseline and after 2 and 4\u2009h on each study day. Pulse wave analysis and velocity were measured at baseline and after 4\u2009h on each study day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to water, milk intake increased ionized calcium levels by 0.02\u2009mmol\/L (<jats:italic>p<\/jats:italic>\u2009=\u2009.029) and decreased parathyroid hormone levels by 1.78\u2009pmol\/L (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The two interventions caused no changes as measured 4\u2009h\u00a0after the intervention in the following indices of cardiovascular health; pulse wave velocity, brachial diastolic or systolic blood pressure, central diastolic or systolic blood pressure, mean arterial pressure, pulse pressure, augmentation pressure, augmentation index, heart rate or pulse transit time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite significant changes in calcium homeostasis with increased levels of ionized calcium following milk intake, no acute effects seem to occur on measures of cardiovascular health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14632","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T11:24:55Z","timestamp":1636543495000},"page":"812-818","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The acute effects of milk intake on calcium homeostasis and cardiovascular outcome: A randomized crossover trial in postmenopausal women"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7464-6785","authenticated-orcid":false,"given":"Rasmus","family":"Espersen","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Internal Medicine Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2152-4247","authenticated-orcid":false,"given":"Lars","family":"Rejnmark","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus 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