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It is associated with dyslipidaemia and elevated plasma C\u2010reactive protein (CRP), which increase the risks of cardiovascular disease (CVD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To review the existing evidence on the effects of different pharmacological interventions on lipid profiles and CRP of women with PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>We searched PubMed, MEDLINE, Scopus, Embase, Cochrane Library, and Web of Science in April 2020 and updated the results in March 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Selection<\/jats:title><jats:p>The study included randomized controlled trials (RCTs) and follows the 2020 Preferred Reporting Items for Systematic reviews and Meta\u2010Analyses (PRISMA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Extraction<\/jats:title><jats:p>Two independent researchers extracted data and assessed for risk of bias using the Cochrane risk of bias tool. Covidence systematic review software were used for blinded screening and study selection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Synthesis<\/jats:title><jats:p>In 29 RCTs, there were significant reductions in triglycerides with atorvastatin versus placebo [mean difference (MD): \u22120.21\u2009mmol\/L; 95% confidence interval (CI): \u22120.39, \u22120.03, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%, moderate grade evidence]. Significant reductions were seen for low\u2010density lipoprotein cholesterol (LDL\u2010C) with metformin versus placebo [standardized mean difference (SMD): \u22120.41; 95% CI: \u22120.85, 0.02, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200959%, low grade evidence]. Significant reductions were also seen for total cholesterol with saxagliptin versus metformin (MD: \u22120.15\u2009mmol\/L; 95% CI: \u22120.23, \u22120.08, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%, very low grade evidence). Significant reductions in C\u2010reactive protein (CRP) were seen for atorvastatin versus placebo (MD: \u22121.51\u2009mmol\/L; 95% CI: \u22123.26 to 0.24, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200975%, very low\u2010grade evidence).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There were significant reductions in the lipid parameters when metformin, atorvastatin, saxagliptin, rosiglitazone and pioglitazone were compared with placebo or other agents. There was also a significant reduction of CRP with atorvastatin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14636","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T04:15:07Z","timestamp":1636949707000},"page":"443-459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of pharmacological interventions on lipid profiles and C\u2010reactive protein in polycystic ovary syndrome: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6016-3157","authenticated-orcid":false,"given":"Mohammed A.","family":"Abdalla","sequence":"first","affiliation":[{"name":"Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School (HYMS) The University of Hull Hull 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