{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:27:32Z","timestamp":1783643252663,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Normocalcemic primary hyperparathyroidism (nPHPT) is defined by an inappropriately increased serum PTH with normal serum calcium. Information about the diagnostic yield of parathyroid SPECT\/CT scan and ultrasonography in nHPPT is limited and not conclusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the positivity rate of <jats:sup>99m<\/jats:sup>Tc\u2010Sestamibi SPECT\/CT scan in nPHTP compared with classical hypercalcemic PHPT (cPHPT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We retrospectively studied 125 patients with <jats:sup>99m<\/jats:sup>Tc\u2010Sestamibi SPECT\/CT scans. Subjects were divided into 2 groups: cPHPT (<jats:italic>n<\/jats:italic>\u2009=\u200993) and nPHPT (<jats:italic>n<\/jats:italic>\u2009=\u200932).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The detection rate of <jats:sup>99m<\/jats:sup>Tc\u2010Sestamibi SPECT\/CT in cPHPT was 86,02% (80\/93) and 59.37%, in nPHPT (19\/32), <jats:italic>p<\/jats:italic>\u2009=\u2009.003. No significant differences were seen between the SPECT\/CT scan and ultrasonography (<jats:italic>p<\/jats:italic>\u2009=\u2009.28) and the agreement was higher in cPHPT than in nPHPT, <jats:italic>p<\/jats:italic>\u2009=\u2009.03. Sensitivity of <jats:sup>99m<\/jats:sup> Tc\u2010Sestamibi\u2010SPECT\/CT was 98% on a per\u2010patient basis (PPV 96%) and 91% on a per\u2010lesion basis (PPV 88%). Glandular size was smaller in nPHPT (mean value 6.8\u2009mm) and it was related only with PTH value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Localization rate of parathyroid hyperfunctioning tissue with <jats:sup>99m<\/jats:sup>Tc\u2010Sestamibi SPECT\/CT is lower in nPHPT and it is related to a smaller glandular size. However, our study suggests that the positivity rate and sensitivity are nonnegligible by adding SPECT\/CT. The reduction in the detection rate in nPHPT could benefit techniques with higher resolution such as <jats:sup>18<\/jats:sup>F\u2010Choline PET\/CT when the clinical context justifies it.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14667","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T06:28:04Z","timestamp":1640327284000},"page":"831-836","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Normocalcemic primary hyperparathyroidism: 99mTc SestaMibi SPECT\/CT results compare with hypercalcemic hyperparathyroidism"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9840-7225","authenticated-orcid":false,"given":"Martina","family":"Musumeci","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda Valeria","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"San Miguel","sequence":"additional","affiliation":[{"name":"Data analysis Department Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"Cianciarelli","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana Cecilia","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"Mollerach","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene Josefa","family":"Arma","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Hume","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"Galich","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Collaud","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1763"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1414"},{"key":"e_1_2_8_4_1","article-title":"Normocalcemic hyperparathyroidism: study of its prevalence and natural history","volume":"105","author":"Schini M","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000491036"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3716-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1870-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2018.09.009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP15704.OR"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2019.10.032"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-018-4512-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021404"},{"key":"e_1_2_8_13_1","first-page":"797","article-title":"Normocalcemic primary hyperparathyroidism: a comparison with the hypercalcemic form in a tertiary referral population","volume":"11","author":"Pierreux J","year":"2018","journal-title":"Horm Metab Res"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-012-1438-y"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1157\/13109149"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0035"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-019-01782-1"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.2310"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2019.0574"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26201"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-018-0931-z"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.104"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1215"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1417"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14667","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14667","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T14:04:05Z","timestamp":1692972245000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,4]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/cen.14667"],"URL":"https:\/\/doi.org\/10.1111\/cen.14667","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,4]]},"assertion":[{"value":"2021-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}