{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:35:34Z","timestamp":1754397334621,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Androgen abuse is relatively common amongst young (amateur) bodybuilders. After cessation, the hypothalamic\u2010pituitary\u2010gonadal (HPG) axis\u2014which has been suppressed by the androgens\u2014needs time to recover. The endogenous testosterone production often recovers within 3 months, however, prolonged or permanent post\u2010androgen abuse hypogonadism (PPAAH) has been described. There is no widely accepted definition nor is its pathogenesis completely elucidated. To date it is a subject of debate whether PPAAH is a separate entity, reflecting irreversible damage to essential components of the HPG axis inflicted by long\u2010term exposure to high doses of androgens. Alternately, it may be the result of longer than expected suppressive effects of androgen depots, undisclosed ongoing androgen abuse or undiagnosed unrelated disorders. Due to the lack of scientific evidence, the management of PPAAH is challenging. By combining clinical experience with evidence from the recent literature, a suggested outline of the management of androgen\u2010abuse\u2010induced hypogonadism are given.<\/jats:p>","DOI":"10.1111\/cen.14686","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T11:49:45Z","timestamp":1644320985000},"page":"469-472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical question: How to manage symptoms of hypogonadism in patients after androgen abuse?"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5001-4748","authenticated-orcid":false,"given":"Esm\u00e9e","family":"Botman","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Spaarne Gasthuis Haarlem the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diederik L.","family":"Smit","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Elizabeth\u2010Tweesteden Ziekenhuis Tilburg the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem","family":"de Ronde","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Spaarne Gasthuis Haarlem the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2014.01.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-19-0557"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.12850"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab129"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnab001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13592"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa366"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0462"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz324"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68614-5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.52082\/jssm.2021.328"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0422"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13011-019-0206-5"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14686","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14686","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T06:37:26Z","timestamp":1692686246000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,17]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/cen.14686"],"URL":"https:\/\/doi.org\/10.1111\/cen.14686","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"type":"print","value":"0300-0664"},{"type":"electronic","value":"1365-2265"}],"subject":[],"published":{"date-parts":[[2022,2,17]]},"assertion":[{"value":"2021-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}