{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:29:55Z","timestamp":1788470995458,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Preoperative location of hyperfunctioning parathyroid glands (HPGs) is vital when planning minimally invasive surgery in patients with primary hyperparathyroidism (PHPT). Dual\u2010isotope subtraction scintigraphy with\n                      <jats:sup>99m<\/jats:sup>\n                      Tc\u2010MIBI\/\n                      <jats:sup>123<\/jats:sup>\n                      Iodide using SPECT\/CT and planar pinhole imaging (Di\u2010SPECT) has shown high sensitivity, but is challenged by high radiation dose, time consumption and cost.\n                      <jats:sup>11<\/jats:sup>\n                      C\u2010Choline PET\/CT (faster with a lower radiation dose) is non\u2010inferior to Di\u2010SPECT. We aim to clarify to what extent the two are interchangeable and how often there are discrepancies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This is a prospective, GCP\u2010controlled cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Measurements<\/jats:title>\n                    <jats:p>One hundred patients diagnosed with PHPT were included and underwent both imaging modalities before parathyroidectomy. Clinical implications of differences between imaging findings and negative imaging results were assessed. Surgical findings confirmed by biochemistry and pathology served as reference standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 90 patients cured by parathyroidectomy, sensitivity was 82% (95% confidence interval [CI]: 74%\u201388%) and 87% (95% CI: 79%\u201392%) for Choline PET and Di\u2010SPECT, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.88.\u00a0In seven cases at least one imaging modality found no HPG. Of these, neither modality found any true HPGs and only two were cured by surgery. When a positive finding in one modality was incorrect, the alternative modality was correct in approximately half of the cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Choline PET and Di\u2010SPECT performed equally well and are both appropriate as first\u2010line imaging modalities for preoperative imaging of PHPT. When the first\u2010line modality fails to locate an HPG, additional preoperative imaging with the alternate modality offers no benefit. However, if parathyroidectomy is unsuccessful, additional imaging with the alternate modality has merit before repeat surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.14688","type":"journal-article","created":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T06:58:19Z","timestamp":1644649099000},"page":"258-267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Preoperative imaging in primary hyperparathyroidism: Are\n                    <sup>11<\/sup>\n                    C\u2010Choline PET\/CT and\n                    <sup>99m<\/sup>\n                    Tc\u2010MIBI\/\n                    <sup>123<\/sup>\n                    Iodide subtraction SPECT\/CT interchangeable or do they supplement each other?"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2680-0121","authenticated-orcid":false,"given":"Julie W.","family":"Christensen","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Herlev and Gentofte Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afefah","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Herlev and Gentofte Hospital Herlev Denmark"},{"name":"Department of Clinical Physiology and Nuclear Medicine Bispebjerg and Frederiksberg Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3390-5637","authenticated-orcid":false,"given":"Susanne B.","family":"S\u00f8ndergaard","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Herlev and Gentofte Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2301-2878","authenticated-orcid":false,"given":"Finn N.","family":"Bennedb\u00e6k","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine Herlev and Gentofte Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9540-4950","authenticated-orcid":false,"given":"Birte","family":"Nygaard","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine Herlev and Gentofte Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1846-4498","authenticated-orcid":false,"given":"Lars T.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Herlev and Gentofte Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemar","family":"Trolle","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Neck Surgery North Zealand Hospital Hilleroed Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoffer","family":"Holst\u2010Hahn","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Neck Surgery Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zerahn","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Herlev and Gentofte Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bent","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Herlev and Gentofte Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2191-1861","authenticated-orcid":false,"given":"Martin","family":"Krakauer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Herlev and Gentofte Hospital Herlev Denmark"},{"name":"Department of Clinical Physiology and Nuclear Medicine Bispebjerg and Frederiksberg Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60507-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.112.105122"},{"key":"e_1_2_9_4_1","unstructured":"Rejnmark L. Danish Endocrine Society \u2013 Treatment guideline for Primary hyperparathyroidism. [website]. October 2018. 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