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Subjects with lateralisation index (LI) of \u22654 were treated with unilateral adrenalectomy, and the immunohistochemical subtype was determined with CYP11B2 and CYP11B1 stains. The performance of adrenal androgens was evaluated by receiver operating characteristics (ROC) curve analyses in adrenalectomy and medical therapy groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During AVS, the correlations between cortisol and androstenedione, DHEA and DHEAS for LI and selectivity index (SI) were highly significant. The right and left side SIs for androstenedione and DHEA were higher (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) than for cortisol. In ROC analysis, the optimal LI cut\u2010off values for androstenedione, DHEA and DHEAS were 4.2, 4.5 and 4.6, respectively. The performance of these LIs for adrenal androgens did not differ from that of cortisol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Under cosyntropin\u2010stimulated AVS, the measurement of androstenedione and DHEA did not improve the cannulation selectivity. The performance of cortisol and adrenal androgens are confirmatory but not superior to cortisol\u2010based results in lateralisation diagnostics of PA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14691","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T18:10:31Z","timestamp":1644948631000},"page":"241-249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Adrenal androgens versus cortisol for primary aldosteronism subtype determination in adrenal venous sampling"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9720-5026","authenticated-orcid":false,"given":"Marianna","family":"Viukari","sequence":"first","affiliation":[{"name":"Endocrinology Helsinki University Hospital and University of Helsinki  Helsinki 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