{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:47:35Z","timestamp":1773276455346,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Coronavirus disease 2019 (COVID\u201019) is associated with high rates of morbidity and mortality. Primary hypothyroidism is a common comorbid condition, but little is known about its association with COVID\u201019 severity and outcomes. This study aims to identify the frequency of hypothyroidism in hospitalized patients with COVID\u201019 as well as describe the differences in outcomes between patients with and without pre\u2010existing hypothyroidism using an observational, multinational registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In an observational cohort study we enrolled patients 18 years or older, with laboratory\u2010confirmed severe acute respiratory syndrome coronavirus\u20102 infection between March 2020\u00a0and February 2021. The primary outcomes were (1) the disease severity defined as per the World Health Organization Scale for Clinical Improvement, which is an ordinal outcome corresponding with the highest severity level recorded during a patient's index COVID\u201019 hospitalization, (2) in\u2010hospital mortality\u00a0and (3) hospital\u2010free days. Secondary outcomes were the rate of intensive care unit (ICU) admission and ICU mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 20,366 adult patients included in the study, pre\u2010existing hypothyroidism was identified in 1616 (7.9%). The median age for the Hypothyroidism group was 70 (interquartile range: 59\u201380) years, and 65% were female and 67% were White. The most common comorbidities were hypertension (68%), diabetes (42%), dyslipidemia (37%)\u00a0and obesity (28%). After adjusting for age, body mass index, sex, admission date in the quarter year since March 2020, race, smoking history\u00a0and other comorbid conditions (coronary artery disease, hypertension, diabetes\u00a0and dyslipidemia), pre\u2010existing hypothyroidism was not associated with higher odds of severe disease using the World Health Organization disease severity index (odds ratio [OR]: 1.02; 95% confidence interval [CI]: 0.92, 1.13;\u00a0<jats:italic>p<\/jats:italic>\u2009=\u2009.69), in\u2010hospital mortality (OR: 1.03;\u00a095% CI: 0.92, 1.15;\u00a0<jats:italic>p<\/jats:italic>\u2009=\u2009.58) or differences in hospital\u2010free days (estimated difference 0.01 days;\u00a095% CI:\u00a0\u22120.45, 0.47;\u00a0<jats:italic>p<\/jats:italic>\u2009=\u2009.97). Pre\u2010existing hypothyroidism was not associated with ICU admission or ICU mortality in unadjusted as well as in adjusted analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In an international registry, hypothyroidism was identified in around 1 of every 12 adult hospitalized patients with COVID\u201019. Pre\u2010existing hypothyroidism in hospitalized patients with COVID\u201019 was not associated with higher disease severity or increased risk of mortality or ICU admissions. However, more research on the possible effects of COVID\u201019 on the thyroid gland and its function is needed in the future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14699","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T17:30:22Z","timestamp":1645205422000},"page":"85-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association of hypothyroidism with outcomes in hospitalized adults with COVID\u201019: Results from the International SCCM Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID\u201019 Registry"],"prefix":"10.1111","volume":"101","author":[{"given":"Marija","family":"Bogojevic","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Pulmonary and Critical Care Medicine Multidisciplinary Epidemiology and Translational Research in Intensive Care Group (METRIC), Mayo Clinic Rochester Minnesota 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