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Little is known about what factors are associated with potential quality of life (QOL) impairments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>HypoPT patients at a minimum of 6\u2009months' post diagnosis were invited to participate in an online survey through their treating physician or through self\u2010help organisations<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Impairments of clinical importance in QOL were considered present if the score of the respective functioning scale of the European Organization for Research and Treatment of Cancer (EORTC) QLQ\u2010C30 exceeded a pre\u2010defined threshold. Symptom burden was assessed using the HPQ\u201028. Multivariate logistic regression was used to identify factors associated with impairments in QOL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were available for 264 hypoPT patients. Impairments of clinical importance in QOL were reported for 40.4% in role functioning (RF), 40.6% in social functioning (SF), 60.8% in physical functioning (PF), 65.5% in cognitive functioning (CF) and 76.0% in emotional functioning (EF). Higher odds for reporting impaired QOL were seen for higher symptom burden (for almost all domains) and for being unable to work (for PF, RF and SF). Surgery for thyroid cancer being the cause of hypoPT was associated with lower odds in PF for patients and in PF and CF for patients with surgery for other thyroid\u2010related diseases being the hypoPT cause.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HypoPT needs to be recognised as a disease which might be associated with impaired QOL and affect daily living. Symptom management is crucial for improving QOL in hypoPT patients but socioeconomic factors like work\u2010ability need to be considered when treating hypoPT patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14701","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T15:49:40Z","timestamp":1645544980000},"page":"268-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["What are predictors of impaired quality of life in patients with hypoparathyroidism?"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7000-8257","authenticated-orcid":false,"given":"Matthias","family":"B\u00fcttner","sequence":"first","affiliation":[{"name":"Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI) University Medical Center Mainz  Mainz Germany"},{"name":"University Medical Center Mainz University Cancer Centre  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Krogh","sequence":"additional","affiliation":[{"name":"Netzwerk Hypopara im Bundesverband Schilddr\u00fcsenkrebs \u2013 Ohne Schilddr\u00fcse leben e.V.  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heide","family":"Siggelkow","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology and Endocrinology University of G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Singer","sequence":"additional","affiliation":[{"name":"Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI) University Medical Center Mainz  Mainz Germany"},{"name":"University Medical Center Mainz University Cancer Centre  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0628"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0803050"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-01858-4"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1477"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1979"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2501"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2004"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1377-3"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-020-00759-8"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-02430"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01471"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01555"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2018.07.010"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"e_1_2_11_16_1","first-page":"\u200b","article-title":"the EORTC quality of life group the EORTC QLQ\u2010C30 scoring manual 3rd edition: European organisation for research and treatment of cancer","author":"Fayers PMAN","year":"2001","journal-title":"Brussels"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10245"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.10.003"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12123590"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jhn.12877"},{"key":"e_1_2_11_21_1","first-page":"\u200b","article-title":"Self\u2010perceived cognitive functioning and quality of life among cancer survivors: results from the PROFILES registry","author":"Oerlemans S","year":"2021","journal-title":"J Cancer Surviv"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10479"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa597"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14128"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP13328.OR"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1460215"},{"issue":"3","key":"e_1_2_11_27_1","first-page":"319","article-title":"Self\u2010report of psychological symptoms in hypoparathyroidism patients on conventional therapy","volume":"62","author":"Arneiro AJ","year":"2018","journal-title":"Arch Endocrinol Metab"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.13051"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319843079"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29808"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2013.001322"},{"key":"e_1_2_11_32_1","unstructured":"RentenversicherungD. 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