{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:14:40Z","timestamp":1780539280422,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Large population\u2010based studies on maternal hyperthyroidism's effect on antepartum, intrapartum, and neonatal complications are few. Most of these studies were small or did not evaluate a broad scope of possible complications. Therefore, a large population\u2010based cohort study was conducted to study the associations between maternal hyperthyroidism and pregnancy and perinatal complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This is a retrospective population\u2010based cohort study utilizing data from the Healthcare Cost and Utilization Project\u2010Nationwide Inpatient Sample over 11 years from 2004 to 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>16,984 deliveries to women with hyperthyroidism and 9,079,804 deliveries to mothers who did not suffer of hyperthyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of all deliveries between 2004 and 2014 inclusively was created. Within this group, all deliveries to women with hyperthyroidism were the study group (<jats:italic>n<\/jats:italic>\u2009=\u200916,984) and the remaining deliveries were categorized as nonhyperthyroidism births and comprised the reference group (<jats:italic>n<\/jats:italic>\u2009=\u20099,079,804). The main outcome measures were pregnancy and perinatal complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal hyperthyroidism was associated with several pregnancy and perinatal complications, including increased risks of gestational hypertension (adjusted odds ratio [aOR]: 1.236, 95% confidence interval [CI]: 1.045\u20131.462, <jats:italic>p<\/jats:italic>\u2009=\u2009.013) and preeclampsia (aOR: 1.190, 95% CI: 1.006\u20131.408, <jats:italic>p<\/jats:italic>\u2009=\u2009.042). These patients are more likely to experience preterm premature rupture of membranes (aOR: 1.322, 95% CI: 1.007\u20131.735, <jats:italic>p<\/jats:italic>\u2009=\u2009.044), preterm delivery (aOR: 1.287 95% CI: 1.132\u20131.465, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), placental previa (aOR: 1.527, 95% CI: 1.082\u20132.155, <jats:italic>p<\/jats:italic>\u2009=\u2009.016), and suffer from venous thromboembolism (aOR: 2.894, 95% CI: 1.293\u20136.475, <jats:italic>p<\/jats:italic>\u2009=\u2009.010).<\/jats:p><jats:p>As for neonatal outcomes, small for gestational age and stillbirth were more likely to occur in the offspring of women with hyperthyroidism (aOR: 1.688, 95% CI: 1.437\u20131.984, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001 and aOR: 1.647, 95% CI: 1.109\u20132.447, <jats:italic>p<\/jats:italic>\u2009=\u2009.013, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with hyperthyroidism are more likely to experience pregnancy, delivery, and neonatal complications. We found an association between hyperthyroidism and hypertensive disorders, preterm delivery, and intrauterine fetal death.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14713","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T08:58:35Z","timestamp":1646816315000},"page":"347-354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Associations between hyperthyroidism and adverse obstetric and neonatal outcomes: A study of a population database including almost 17,000 women with hyperthyroidism"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1466-7178","authenticated-orcid":false,"given":"Ranit","family":"Hizkiyahu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Mcgill University  Montreal Qu\u00e9bec 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