{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:51:58Z","timestamp":1792547518027,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In clinical practice, false\u2010positive results in biochemical testing for suspected pheochromocytoma\/paraganglioma (PPGL) are not infrequent and may lead to unnecessary examinations. We aimed to evaluate the role of the clonidine suppression test (CST) in the era of analyses of plasma\u2010free metanephrines for the diagnosis or exclusion of PPGL in patients with adrenal tumours and\/or arterial hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Methods<\/jats:title><jats:p>This single\u2010centre, prospective trial investigated the use of CST in 60 patients with suspected PPGL associated with out\u2010patient elevations of plasma normetanephrine (NMN) and\/or metanephrine (MN), in most cases accompanied with hypertension or an adrenal mass. Measurements of plasma catecholamines and free metanephrines were performed by liquid chromatography with electrochemical detection and tandem mass spectrometry, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six patients entered final analysis (<jats:italic>n<\/jats:italic>\u2009=\u200920 with PPGL and <jats:italic>n<\/jats:italic>\u2009=\u200926 with a nonfunctional adrenal mass and\/or hypertension). CST reliably excluded false\u2010positive baseline NMN results with a specificity of 100%. The sensitivity of CST improved from 85% to 94% when tumours with isolated MN increase (<jats:italic>n<\/jats:italic>\u2009=\u20093) were not considered. In patients with elevated baseline NMN (<jats:italic>n<\/jats:italic>\u2009=\u200924), CST correctly identified all patients without PPGL. Patients with falsely elevated baseline NMN results (<jats:italic>n<\/jats:italic>\u2009=\u20097, 26.9%) exhibited increases of baseline NMN up to 1.7\u2010fold above the upper reference limit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CST qualifies as a useful diagnostic tool for differential diagnosis of borderline elevated plasma\u2010free NMN in patients with suspected PPGL. In this context, CST helps to correctly identify all false\u2010positive NMN screening results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14724","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T10:12:04Z","timestamp":1646993524000},"page":"541-550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Clonidine suppression test for a reliable diagnosis of pheochromocytoma: When to use"],"prefix":"10.1111","volume":"97","author":[{"given":"Spyridoula","family":"Tsiomidou","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, Endocrine Tumour Centre at WTZ and Member of ENDO\u2010ERN, University Hospital Essen University Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Pamporaki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Geroula","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Van Baal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, Endocrine Tumour Centre at WTZ and Member of ENDO\u2010ERN, University Hospital Essen University Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Weber","sequence":"additional","affiliation":[{"name":"Division of Endocrine Surgery, Endocrine Tumour Centre at WTZ and Member of ENDO\u2010ERN, University Hospital Essen University Duisburg\u2010Essen Essen 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