{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:17:41Z","timestamp":1792210661227,"version":"4.4.0"},"reference-count":113,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This review provides an overview of novel insights in the clinical management of patients with Multiple Endocrine Neoplasia Type 1, focusing on the last decade since the last update of the MEN1 guidelines. With regard to\n                    <jats:italic>Diagnosis<\/jats:italic>\n                    : Mutation\u2010negative patients with 2\/3 main manifestations have a different clinical course compared to mutation\u2010positive patients. As for\n                    <jats:italic>primary hyperparathyroidism<\/jats:italic>\n                    : subtotal parathyroidectomy is the initial procedure of choice. Current debate centres around the timing of initial parathyroidectomy as well as the controversial topic of unilateral clearance in young patients. For\n                    <jats:italic>duodenopancreatic neuroendocrine tumours<\/jats:italic>\n                    (NETs), the main challenge is accurate and individualized risk stratification to enable personalized surveillance and treatment.\n                    <jats:italic>Thymus NETs<\/jats:italic>\n                    remain one of the most aggressive MEN1\u2010related tumours.\n                    <jats:italic>Lung NETs<\/jats:italic>\n                    are more frequent than previously thought, generally indolent, but rare aggressive cases do occur.\n                    <jats:italic>Pituitary adenomas<\/jats:italic>\n                    are most often prolactinomas and nonfunctioning microadenomas with an excellent prognosis and good response to therapy\n                    <jats:italic>. Breast cancer<\/jats:italic>\n                    is recognized as part of the MEN1 syndrome in women and periodical screening is advised. Clinically relevant manifestations are already seen at the\n                    <jats:italic>paediatric<\/jats:italic>\n                    age and initiating screening in the second decade is advisable. MEN1 has a significant impact on\n                    <jats:italic>quality of life<\/jats:italic>\n                    and US data show a significant financial burden. In conclusion, patient outcomes have improved, but much is still to be achieved. For care tailored to the needs of the individual patient and improving outcomes on an individual basis, studies are now needed to define predictors of tumour behaviour and effects of more individualized interventions.\n                  <\/jats:p>","DOI":"10.1111\/cen.14727","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T05:10:08Z","timestamp":1648012208000},"page":"409-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Update on the clinical management of multiple endocrine neoplasia type 1"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4894-373X","authenticated-orcid":false,"given":"Carolina R. C.","family":"Pieterman","sequence":"first","affiliation":[{"name":"Department of Endocrine Oncology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerlof D.","family":"Valk","sequence":"additional","affiliation":[{"name":"Department of Endocrine Oncology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5311.404"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1230"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0708-1"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01170"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1406028"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03324.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0290-1"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.12.8070"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-18-0359"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3182954af1"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3171\/2020.1.JNS193538"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000435921"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14067"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-018-0938-8"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13119"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00533"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2020.04.067"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.06.051"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1668"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00837"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0210"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3766"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa257"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3659"},{"key":"e_1_2_12_26_1","article-title":"Multiple endocrine neoplasia type 1 in children and adolescents: clinical features and treatment outcomes","author":"Shariq OA","year":"2021","journal-title":"Surgery"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1322-5"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.06.065"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-019-05186-1"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090304"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.125"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0153"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.134.10.1119"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2018.04.064"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2020.08.021"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-015-1342-7"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.2310"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00618"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-016-3624-9"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00123"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67424-5"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14112"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4865-9"},{"issue":"12","key":"e_1_2_12_44_1","first-page":"3515","article-title":"Initiating pancreatic neuroendocrine tumour (pNET) screening in young MEN1 patients: results from the DutchMEN Study Group","volume":"106","author":"Klein Haneveld MJ","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11632"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000112297.72510.32"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25667"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003162"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.11.8011"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP161639.OR"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000189549.51913.d8"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2000.109727"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-4432"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2017.04.044"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12552"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-017-4019-2"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-00372"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt039"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-19-0372"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1159\/000511791"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2019.101318"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2020.09.037"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322595"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0493-4"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06498-2"},{"issue":"12","key":"e_1_2_12_66_1","first-page":"e4969","article-title":"A blood\u2010based polyamine signature associated with MEN1 duodenopancreatic neuroendocrine tumor progression","volume":"106","author":"Fahrmann JF","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063364"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1210\/js.2018-00087"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.654975"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-017-3992-9"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.2217\/ije-2017-0018"},{"key":"e_1_2_12_72_1","article-title":"Metastatic patterns of duodenopancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1","author":"Hackeng WM","year":"2021","journal-title":"Am J Surg Pathol"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14430"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1410"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1159\/000357779"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0878"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.09.017"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-02754"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14406"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002050"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-09496-1"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz007"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13480"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-015-0228-z"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04467.x"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-9980-y"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021314"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1155"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1560"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-016-0269-y"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199701000-00002"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01619.x"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.07.020"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-015-0228-z"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-017-4135-z"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa800"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20825"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1210\/JC.2015-2015"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-21-0630"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-019-00939-x"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31815ade45"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-3690"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.7326\/M15-1536"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1768"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00597"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023252107120"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-006-9047-2"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.09.010"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2017.07.010"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2017.07.023"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2017.04.030"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508374"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00259"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-020-01650-y"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14727","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14727","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T16:31:27Z","timestamp":1692721887000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":113,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/cen.14727"],"URL":"https:\/\/doi.org\/10.1111\/cen.14727","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"2021-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}