{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:26:04Z","timestamp":1791563164461,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Active acromegaly is subject to sex differences in growth hormone (GH) and Insulin like growth factor 1 (IGF\u2010I) patterns as well as clinical features but whether this also pertains to controlled disease is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>In a cross\u2010sectional, multi\u2010centre study, 84 patients with acromegaly (<jats:italic>F<\/jats:italic>\u2009=\u200943, <jats:italic>M<\/jats:italic>\u2009=\u200941), who were considered controlled after surgery alone (<jats:italic>n<\/jats:italic>\u2009=\u200923) or during continued somatostatin receptor ligand (SRL) treatment (<jats:italic>n<\/jats:italic>\u2009=\u200961), were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum concentrations of GH, insulin, glucose and free fatty acid (FFA) were measured during an oral glucose tolerance test (OGTT) together with baseline serum IGF\u2010I and completion of two HR\u2010Qol questionnaires (acromegaly quality of life questionnaire [AcroQol] and Patient\u2010assessed Acromegaly Symptom Questionnaire [PASQ]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age at the time of the study was 57 (\u00b11.1) years and the majority of females (were postmenopausal. Females had significantly higher fasting GH but comparable IGF\u2010I standard deviation scores (SDS). Using fasting GH\u2009&lt;\u20091.0\u2009\u00b5g\/L as cut off, disease control was less prevalent in females (F: 56% vs. M: 83%, <jats:italic>p<\/jats:italic>\u2009=\u2009.007) whereas a comparable figure was observed using IGF\u2010I SDS\u2009&lt;\u20092 (F:79% vs. M:76%, <jats:italic>p<\/jats:italic>\u2009=\u2009.71). Compared with males, female patients showed impaired AcroQol physical score (<jats:italic>p<\/jats:italic>\u2009=\u2009.05), higher fasting FFA (<jats:italic>p<\/jats:italic>\u2009=\u2009.03) and insulin concentrations during the OGTT (<jats:italic>p<\/jats:italic>\u2009=\u2009.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with acromegaly considered controlled, postmenopausal females exhibited higher GH levels than males despite comparable IGF\u2010I levels, which also translated into impaired metabolic health and well\u2010being. Our findings point to the relevance of including GH measurements in the assessment of disease control and suggest that disease\u2010specific sex differences prevail after treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14750","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T04:21:27Z","timestamp":1651033287000},"page":"74-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Sex difference in patients with controlled acromegaly\u2014A multicentre survey"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0610-7867","authenticated-orcid":false,"given":"Jakob","family":"Dal","sequence":"first","affiliation":[{"name":"Department of Endocrinology Aalborg University Hospital Aalborg Denmark"},{"name":"Steno Diabetes Centre North Jutland Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Rosendal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6026-5834","authenticated-orcid":false,"given":"Jesper","family":"Karmisholt","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Feldt\u2010Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism National University Hospital Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences Copenhagen University Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne S.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Klose","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism National University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"feltoft","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Herlev University Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar","family":"Heck","sequence":"additional","affiliation":[{"name":"Section of Specialized Endocrinology, Oslo University Hospital and Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eigil H.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens O. 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