{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:52:31Z","timestamp":1761709951458,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T00:00:00Z","timestamp":1654992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Degenerative lumbar scoliosis (DLS) is an age\u2010related spinal disease. It is an important cause of low back pain, lower limb pain\u00a0and intermittent claudication, which seriously affects the quality of life of middle\u2010aged and elderly people. <jats:bold>Design:<\/jats:bold> This article aims to study the changes in serum oestrogen levels in postmenopausal women with DLS and its relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>One hundred and sixty\u2010eight\u00a0postmenopausal women diagnosed with DLS (DLS group) and 140 healthy postmenopausal women (control group) were recruited. <jats:bold>Measurements:<\/jats:bold> Lumbar spinal bone mineral density (LSBMD) was measured by dual\u2010energy X\u2010ray absorptiometry\u00a0and a chemiluminescence immunoassay analyser was used to detect serum \u03b2\u2010oestradiol (E2) levels. The severity of lower back pain\u00a0was assessed by the visual analogue scale\u00a0score and dysfunction was evaluated by Oswestry Disability Index (ODI). The quality of life was evaluated by Medical Outcomes Study 36\u2011item Short Form Health Survey (SF\u201136). Diagnostic efficiency was evaluated by the receiver\u2010operating characteristics curve (ROC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LSBMD and the level of E2 in the serum in DLS patients were significantly reduced when compared with the control group. The levels of E2 in the serum of postmenopausal women are reliable for predicting DLS revealed by ROC (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Serum E2 levels were negatively correlated with Cobb angle, VAS\u00a0and ODI\u00a0and were positively correlated with LSBMD and SF\u201036 scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In postmenopausal women, serum E2 levels in DLS patients are significantly reduced and low levels of E2 are associated with lower bone density and poorer quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14786","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T06:44:41Z","timestamp":1653979481000},"page":"91-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between serum \u03b2\u2010oestradiol and health\u2010related quality of life in postmenopausal women with degenerative lumbar scoliosis"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3780-7564","authenticated-orcid":false,"given":"Lijun","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Orthopedic Trauma Dept. 2 the Third Hospital of Shijiazhuang, Shijiazhuang  Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Trauma Dept. 2 the Third Hospital of Shijiazhuang, Shijiazhuang  Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheming","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Trauma Dept. 2 the Third Hospital of Shijiazhuang, Shijiazhuang  Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,12]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.3928\/01477447-20170606-02"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1016\/j.nec.2006.05.002"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.3171\/2010.1.FOCUS09271"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1016\/j.spinee.2006.07.015"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1097\/MD.0000000000017177"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1097\/MD.0000000000003394"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1016\/j.yhbeh.2014.08.011"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1155\/2000\/305940"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.3389\/fonc.2015.00019"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.1210\/er.2014-1024"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1053\/joca.1999.0260"},{"key":"e_1_2_8_13_1","first-page":"77","article-title":"Adult degenerative lumbar scoliosis","volume":"32","author":"Daffner SD","year":"2003","journal-title":"Am\u00a0J\u00a0Orthop"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.1097\/BRS.0000000000002904"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.1302\/0301-620X.77B1.7822369"},{"doi-asserted-by":"publisher","key":"e_1_2_8_16_1","DOI":"10.1007\/s00586-011-2048-3"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/s12891-019-2695-9","article-title":"Patients with adolescent idiopathic scoliosis perceive positive improvements regardless of change in the Cobb angle\u2014Results from a randomized controlled trial comparing a 6\u2010month Schroth intervention added to standard care and standard care alone. SOSORT 2018 Award winner","volume":"20","author":"Schreiber S","year":"2019","journal-title":"BMC Musculoskelet Disord"},{"key":"e_1_2_8_18_1","first-page":"2588","article-title":"Heterogeneous consistency loss for Cobb angle estimation","volume":"2021","author":"Guo Y","year":"2021","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3171\/2012.6.SPINE12227","article-title":"Morphometric analysis using multiplanar reconstructed CT of the lumbar pedicle in patients with degenerative lumbar scoliosis characterized by a Cobb angle of 30 degrees or greater","volume":"17","author":"Makino T","year":"2012","journal-title":"J\u00a0Neurosurg"},{"doi-asserted-by":"publisher","key":"e_1_2_8_20_1","DOI":"10.1080\/02688697.2016.1206186"},{"doi-asserted-by":"publisher","key":"e_1_2_8_21_1","DOI":"10.1016\/j.mcna.2020.06.004"},{"doi-asserted-by":"publisher","key":"e_1_2_8_22_1","DOI":"10.1007\/s11657-018-0555-0"},{"doi-asserted-by":"publisher","key":"e_1_2_8_23_1","DOI":"10.1016\/S0749-0690(02)00022-8"},{"doi-asserted-by":"publisher","key":"e_1_2_8_24_1","DOI":"10.1016\/j.wneu.2021.07.101"},{"doi-asserted-by":"publisher","key":"e_1_2_8_25_1","DOI":"10.1210\/jendso\/bvab018"},{"doi-asserted-by":"publisher","key":"e_1_2_8_26_1","DOI":"10.1146\/annurev.med.46.1.249"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14786","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14786","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T22:42:31Z","timestamp":1692484951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,12]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/cen.14786"],"URL":"https:\/\/doi.org\/10.1111\/cen.14786","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"type":"print","value":"0300-0664"},{"type":"electronic","value":"1365-2265"}],"subject":[],"published":{"date-parts":[[2022,6,12]]},"assertion":[{"value":"2022-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}