{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:21:26Z","timestamp":1740126086772,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Hypothalamic dysfunction is characterized by complex aetiologies, multiple forms of onset\u00a0and various clinical symptoms. This study aims to explore the clinical and metabolic characteristics of hypothalamic dysfunction in Chinese children and adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This study is a single\u2010centre, retrospective study that covers patients from 1989 to 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>We included 40 children and adolescents with hypothalamic dysfunction from our medical centre in Beijing, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intracranial tumour (37.5%) was the most common aetiology of children and adolescents with hypothalamic dysfunction, especially germ cell tumours, hypopituitarism (82.5%), weight gain (72.5%)\u00a0and central diabetes insipidus (70.0%) were the most common symptoms in these patients. Furthermore, serum alanine aminotransferase, aspartate aminotransferase, <jats:italic>\u03b3<\/jats:italic>\u2010glutamyl transpeptidase, uric acid, total cholesterol, triglycerides\u00a0and low\u2010density lipoprotein cholesterol\u00a0was significantly higher in hypothalamic dysfunction patients than sex\u2010 and age\u2010matched controls and sex, age and body mass index\u00a0(BMI)\u2010matched controls (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). However, albumin\u00a0and high\u2010density lipoprotein cholesterol\u00a0were lower (<jats:italic>p<\/jats:italic>&lt;\u20090.05). Moreover, 95% (38\/40) of the patients had metabolic diseases. In addition, the incidence of dyslipidaemia and hyperuricemia in children and adolescents with hypothalamic dysfunction was significantly higher than both sex\u2010 and age\u2010matched controls and sex\u2010, age\u2010\u00a0and BMI\u2010matched controls (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) as well.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intracranial tumour was the most common aetiology in children and adolescents with hypothalamic dysfunction. In addition, these patients presented a worse metabolic profile on average than healthy patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14814","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T05:33:14Z","timestamp":1660800794000},"page":"59-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The clinical and metabolic characteristics of children and adolescents with hypothalamic dysfunction: A single\u2010centre study from China"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4182-2890","authenticated-orcid":false,"given":"Xiaoan","family":"Ke","sequence":"first","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, State Key Laboratory of Complex Severe and Rare Diseases, Department of Endocrinology, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical 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