{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:31:08Z","timestamp":1791549068954,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate preconceptual thyroid peroxidase antibody (TPO\u2010ab) positivity and\/or thyroid stimulating hormone (TSH) levels in the upper range of normal as risk factors for recurrent unexplained first\u2010trimester miscarriage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A post\u2010hoc study of a randomized trial, in which acetylsalicylic acid did not affect the risk of a new miscarriage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Women (<jats:italic>n<\/jats:italic>\u2009=\u2009483) with at least three unexplained recurrent first\u2010trimester miscarriages investigated at a Swedish secondary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>The levels of TPO\u2010ab and TSH were determined before pregnancy. The occurrence of a new first\u2010trimester miscarriage was analyzed by logistic regression with adjustments when applicable, for age, number of previous miscarriages, obesity and the investigated covariates levels of TPO\u2010ab and TSH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Including all first trimester miscarriages, odds ratio (OR) according to presence of TPO\u2010ab was 1.60 (95% confidence interval [CI]; 0.99\u20132.57), after adjustment 1.54 (95% CI; 0.94\u20132.53). Very early (biochemical) pregnancy losses occurred more often in women with than without preconceptual TPO\u2010ab (6.8% vs. 2.0%), OR 3.51 (95% CI; 1.15\u201310.71), after adjustment 2.91 (95% CI; 0.91\u20139.29). There was no association between TSH in the upper range of normal and a new miscarriage, adjusted OR 0.76 (95% CI; 0.32\u20131.83). A prediction model for a new miscarriage included number of previous miscarriages, woman's age and presence of TPO\u2010ab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In women with at least three recurrent unexplained pregnancy losses, the presence of TPO\u2010ab may contribute to an increased risk of a first\u2010trimester miscarriage, possibly more pronounced in very early pregnancy. TSH levels 2.5\u20134.0 mU\/L do not seem to increase the miscarriage risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14825","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T05:34:25Z","timestamp":1663911265000},"page":"259-269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Preconceptual thyroid peroxidase antibody positivity in women with recurrent pregnancy losses may contribute to an increased risk for another miscarriage"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4736-1925","authenticated-orcid":false,"given":"Lennart","family":"Blomqvist","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecologist, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Obstetrics and gynaecologists\u00f6dra \u00c4lvsborg's Hospital Bor\u00e5s 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Obstetrics and Gynaecologist, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Obstetrics and Gynaecologist Sahlgrenska University Hospital  Gothenburg 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