{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:38:43Z","timestamp":1788431923595,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014382","name":"Ipsen","doi-asserted-by":"publisher","award":["Unrestricted research grant"],"award-info":[{"award-number":["Unrestricted research grant"]}],"id":[{"id":"10.13039\/501100014382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["Unrestricted research grant"],"award-info":[{"award-number":["Unrestricted research grant"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study time\u2010related changes in the prevalence and patient characteristics of acromegaly, as well as to assess the impact of changes in treatment on disease control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 107 patients with acromegaly were identified by healthcare registries and subsequently validated by patient chart review over a three\u2010decade period (1992\u20132021). A systematic literature review focusing on the incidence and prevalence of acromegaly was performed identifying 31 studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of acromegaly significantly increased throughout the study period (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.94, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and was 122 cases\/10<jats:sup>6<\/jats:sup> persons in 2021 whereas the annual incidence remained constant at 4.6 cases\/10<jats:sup>6<\/jats:sup> persons. The age at the first sign of acromegaly and the age at diagnosis significantly increased during the study period, whereas growth hormone and insulin\u2010like growth factor I decreased. Incidentalomas constituted 32% of all cases diagnosed with acromegaly in the last decade. Primary surgery was used in 93% of all cases, and repeated surgery decreased from 24% to 10% during the three decades. The use of first\u2010generation somatostatin analogues (21%\u201348%) and second\u2010line medical treatment (4%\u201320%) increased with a concomitant improvement of biochemical disease control (58%\u201391%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of acromegaly is higher than previously reported and the clinical presentation has shifted towards a milder phenotype. Modern treatment of acromegaly enables individualized treatment and disease control in the majority of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14828","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T04:24:10Z","timestamp":1664252650000},"page":"773-782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["The prevalence of acromegaly is higher than previously reported: Changes over a three\u2010decade period"],"prefix":"10.1111","volume":"97","author":[{"given":"Charlotte","family":"Aagaard","sequence":"first","affiliation":[{"name":"Department of Endocrinology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda S.","family":"Christophersen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Aalborg University Hospital Aalborg 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