{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:14:20Z","timestamp":1781777660324,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the predictive value of unremarkable nonstimulated highly sensitive thyroglobulin (hsTg) measurement with regard to the results of stimulated thyroglobulin (Tg) measurement,\u00a0diagnostic whole\u2010body scintigraphy,\u00a0recurrence\u00a0and differentiated thyroid cancer\u00a0(DTC)\u2010related death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Patients and Measurements<\/jats:title><jats:p>We retrospectively analysed the data of all 461 (410 without anti\u2010Tg\u2010antibodies [TgAbs], 51 with)\u00a0DTC\u00a0patients who were referred to our department for treatment and follow\u2010up care of differentiated thyroid cancer from 2004 onwards, and in whom at least one posttreatment Tg value was measured in our hospital at least 3 months after I\u2010131 ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the group of TgAb\u2010negative patients, 2.0% of patients with an unstimulated Tg\u2009&lt;\u20090.1\u2009ng\/ml showed a stimulated Tg\u2009\u2265\u20091.0\u2009ng\/ml, whereas this happened in 77.6% with an unstimulated Tg\u2009\u2265\u20090.1 but &lt;1.0\u2009ng\/ml. An unstimulated hsTg\u2009\u2265\u20090.1\u2009ng\/ml had a sensitivity\u00a0specificity\u00a0positive and negative predictive value of 90.0%, 94.1%, 77.6%\u00a0and 97.6%, respectively, for a stimulated Tg\u2009\u2265\u20091.0\u2009ng\/ml. In TgAb\u2010positive patients, this was 75%, 97%, 75%\u00a0and 97%, respectively. An unstimulated Tg\u2009\u2265\u20090.1\u2009ng\/ml did not significantly discriminate with regard to the risk of DTC\u2010related death (<jats:italic>p<\/jats:italic>\u2009=\u2009.06), but \u22651.0\u2009ng\/ml did (<jats:italic>p<\/jats:italic>\u2009=\u2009.012), as did a stimulated Tg\u2009\u2265\u20091.0\u2009ng\/ml (<jats:italic>p<\/jats:italic>\u2009=\u2009.029). Excluding patients with distant metastases at diagnosis nullifies this significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Except for patients with distant metastases, both TgAb negative and TgAb positive patients with an undetectable nonstimulated hsTg measurement have a very good prognosis. The high net present value of unstimulated hsTg testing means that further diagnostic procedures can be omitted in such patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14837","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T07:39:30Z","timestamp":1666251570000},"page":"622-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long\u2010term predictive value of highly sensitive thyroglobulin measurement"],"prefix":"10.1111","volume":"98","author":[{"given":"Larissa R.","family":"B\u00f6gershausen","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine University Hospital Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0230-0974","authenticated-orcid":false,"given":"Luca","family":"Giovanella","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET\u2010Center Oncology Institute of Southern Switzerland Bellinzona Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Stief","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University Hospital Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Luster","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7161-0979","authenticated-orcid":false,"given":"Frederik A.","family":"Verburg","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital Marburg Marburg Germany"},{"name":"Department of Radiology and Nuclear Medicine Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0148"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01819"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1315-6"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-014-2851-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02685.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4137"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-17-0663"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13300"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0891-1839"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0352"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3651"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14837","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14837","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T06:37:16Z","timestamp":1692686236000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/cen.14837"],"URL":"https:\/\/doi.org\/10.1111\/cen.14837","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"2022-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}