{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T02:22:12Z","timestamp":1773109332625,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with acromegaly have often several comorbidities, including decreased quality of life, mood alterations and chronic pain. Mindfulness is effective at improving mood, quality of life and pain management; however, there is no data available on its effect in patients with acromegaly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed at evaluating changes in quality of life, mood, pain, sleep, self\u2010compassion, life satisfaction, blood pressure and heart rate after a mindfulness program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Patients<\/jats:title><jats:p>This was a randomized, multicentre, international clinical trial (Barcelona\u2010BCN and Bergamo\u2010BG) of 60 patients, 30 per centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>The intervention group participated in an 8\u2010week face\u2010to\u2010face group program; the control group followed normal clinical routine. In BG, patients performed a classic Mindfulness Based Stress Reduction program; in BCN they performed an adapted program including elements of mindfulness and compassion with a greater focus on daily life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the BCN intervention group there was an increase in night\u2010time hours in bed (p = 0.05) after the program. In both centres there was a trend to a reduction of the time to start sleeping (p = 0.06 BCN, p = 0.07 BG). In BCN, the intervention group reduced the pain score compared to the control group (p = .02), and an improvement in self\u2010compassion was found (p = .04). In both centres, heart rate decreased significantly in the intervention group during a single 2\u2010hour session. This was evidenced at the first and the last program session (BCN p = .013 and p = .009; BG &lt; 0.001 and p = .04). A training effect was found in BG, where heart rate fell more in the last session than in the first (p = 002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have demonstrated for the first time the value of a mindfulness program in patients with acromegaly, analysing possible effects and advantages, and clarifying the usefulness of a specific protocol for the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14844","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T11:54:55Z","timestamp":1667822095000},"page":"363-374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The effect of mindfulness therapy in acromegaly, a pilot study"],"prefix":"10.1111","volume":"98","author":[{"given":"Alicia","family":"Santos","sequence":"first","affiliation":[{"name":"Endocrinology Department,\u00a0Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER, Unit747) ISCIII, Hospital Sant Pau  Barcelona Spain"},{"name":"Department of Medicine, IIB\u2010Sant Pau Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Nalin","sequence":"additional","affiliation":[{"name":"Meditation and Mindfulness Teacher  Venezia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GianMario","family":"Bortolotti","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Ospedale Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabet","family":"Dominguez\u2010Clave","sequence":"additional","affiliation":[{"name":"Psychiatry Department Hospital Sant Pau  Barcelona Spain"},{"name":"Department of Pharmacology and Therapeutics,\u00a0Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), IIB\u2010Sant Pau Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianola","family":"Daniela","sequence":"additional","affiliation":[{"name":"Malattie Endocrine 1\u2013Diabetologia Ospedale Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liana","family":"Cortesi","sequence":"additional","affiliation":[{"name":"Malattie Endocrine 1\u2013Diabetologia Ospedale Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Pagani","sequence":"additional","affiliation":[{"name":"Malattie Endocrine 1\u2013Diabetologia Ospedale Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A. 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