{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:08:07Z","timestamp":1788815287339,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T00:00:00Z","timestamp":1673222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["e\u201026\/202.7\u2010\u2010\/2019 (244480)"],"award-info":[{"award-number":["e\u201026\/202.7\u2010\u2010\/2019 (244480)"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Although there is growing evidence associating nonfunctioning adrenal incidentalomas (NFAI) with cardiovascular risk factors, there are limited data whether NFAI and autonomous cortisol secretion (ACS) groups have similar or different clinical and metabolic features. The aim of this study is to compare cardiometabolic clinic parameters among patients with ACS and NFAI, as well as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Eighty nine NFAI, 58 ACS and 64 controls were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Diagnosis of NFAI (1\u2009mg dexamethasone suppression test [1\u2009mg\u2010DST] \u226450\u2009nmol\/L [\u22641.8\u2009\u03bcg\/dl]) and ACS (1\u2009mg\u2010DST &gt;\u200950\u2009nmol\/L [&gt;\u20091.8\u2009\u03bcg\/dl]) was established according to current guidelines. The control group was selected based on a normal adrenal imaging exam.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no differences between groups regarding age, gender, ethnicity, menopause or body mass index. Patients with adrenal incidentaloma presented higher frequency of hypertension (74.1 vs. 57.8%; <jats:italic>p<\/jats:italic>\u2009=\u2009.02), resistant hypertension (45.4 vs. 9.4%; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), dyslipidemia (80.1 vs. 63.9%; <jats:italic>p<\/jats:italic>\u2009=\u2009.01), as well as metabolic syndrome (84.2 vs. 61.7%; <jats:italic>p<\/jats:italic>\u2009=\u2009.001) compared to the controls, respectively. NFAI and ACS patients presented similar frequency of arterial hypertension (70.8 vs. 79.3%) and resistant hypertension (41.3 vs. 51.1%), dyslipidemia (79.3 vs. 81.5%) and metabolic syndrome (83.3 vs. 85.7%); also, levels of HbA1c were similar between the groups. Binary logistic regression showed that NFAI (<jats:italic>p<\/jats:italic>\u2009=\u2009.004) and ACS (<jats:italic>p<\/jats:italic>\u2009=\u2009.001) were independent predictors for resistant hypertension (<jats:italic>p<\/jats:italic>\u2009=\u2009.003); also, ACS was an independent predictor for metabolic syndrome (<jats:italic>p<\/jats:italic>\u2009=\u2009.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NFAI and ACS presented a higher frequency of cardiometabolic morbidities in comparison with individuals with normal adrenal glands. Additionally, we demonstrated that both ACS and NFAI groups have similar cardiometabolic conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14861","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T09:19:32Z","timestamp":1671009572000},"page":"662-669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Adrenal incidentaloma: Do patients with apparently nonfunctioning mass or autonomous cortisol secretion have similar or different clinical and metabolic features?"],"prefix":"10.1111","volume":"98","author":[{"given":"Jo\u00e3o Felipe Dickson","family":"Rebelo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Endocrine Unit, School of Medicine, Clementino Fraga Filho University Hospital Federal University of Rio de Janeiro Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Magar\u00e3o","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Endocrine Unit, School of Medicine, Clementino Fraga Filho University Hospital Federal University of Rio de Janeiro Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Damasceno","family":"Junqueira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Endocrine Unit, School of Medicine, Clementino Fraga Filho University Hospital Federal University of Rio de Janeiro Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelmo de Oliveira","family":"Fonseca","sequence":"additional","affiliation":[{"name":"School of Medicine Federal University of Rio de Janeiro Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Beatriz Alcantara B\u00e9renger Samarcos","family":"de 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