{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:52:16Z","timestamp":1747183936009,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["SCU2020D4132"],"award-info":[{"award-number":["SCU2020D4132"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971586","82071874","82102020","82120108015","82271981"],"award-info":[{"award-number":["81971586","82071874","82102020","82120108015","82271981"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Turner syndrome (TS) has an increased predisposition to ischaemic heart disease and the status of coronary microcirculation in TS is largely unknown. This study aims to evaluate myocardial microvascular function in TS using first\u2010pass magnetic resonance perfusion imaging and determine significant risk factors contributing to microvascular dysfunction in the early stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Perspective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>The study cohort consisted of 67 children and youth with TS and 32 age\u2010 and gender\u2010matched controls. Measurements Clinical characteristics, left ventricle (LV) volume and function\u00a0and cardiovascular magnetic resonance\u2010derived myocardial perfusion parameters were assessed. Univariable and multivariable linear regression analyses were performed to assess the potential risk factors for microvascular dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Microvascular perfusion decreased in TS in global and segmented myocardium as reflected in the lower upslope<jats:sub>cor<\/jats:sub> and maximum signal intensity (MaxSI) of LV myocardium compared to controls. Multivariable linear regression analysis indicated that age (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.107, 95% confidence interval [CI]\u2009=\u2009\u22120.201 to \u22120.013, <jats:italic>p<\/jats:italic>\u2009=\u2009.026) and being overweight\/obese (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22121.155, CI\u2009=\u2009\u22122.134 to \u22120.176, <jats:italic>p<\/jats:italic>\u2009=\u2009.021) were independent impact factors of microvascular dysfunction. Subgroup analysis showed the upslope<jats:sub>cor<\/jats:sub> of older patients with TS decreased more significantly compared with that of normal controls. Upslope<jats:sub>cor<\/jats:sub> and MaxSI were lower in overweight\/obese patients with TS than in patients with normal body mass index (BMI) and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Myocardial microvascular dysfunction can occur in children and youth patients with TS. Age and overweight\/obesity were the independent risk factors of microvascular dysfunction, which imply the importance of lowering BMI for the prevention of coronary heart disease in young TS population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14866","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T04:14:15Z","timestamp":1671509655000},"page":"578-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of coronary microvascular dysfunction and risk factors in children and youth with Turner syndrome by magnetic resonance myocardial perfusion imaging"],"prefix":"10.1111","volume":"98","author":[{"given":"Wei","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Radiology, State Key Laboratory of Biotherapy, West China Second University Hospital Sichuan University Chengdu Sichuan China"},{"name":"Key Laboratory of Obstetric &amp; Gynecologic and 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Ministry of Education, West China Second University Hospital Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Radiology, State Key Laboratory of Biotherapy, West China Second University Hospital Sichuan University Chengdu Sichuan China"},{"name":"Key Laboratory of Obstetric &amp; Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Radiology Deyang People's Hospital Deyang Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Su Zhou Municipal Hospital Suzhou Jiangsu 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