{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T15:29:30Z","timestamp":1785079770260,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Patients with Sheehan syndrome (SS) are predisposed to coronary artery disease (CAD) due to risk factors like abdominal obesity, dyslipidemia and chronic inflammation. In addition to estimate CAD risk enhancers like high sensitive C reactive protein (hsCRP), apolipoprotein B (ApoB) and lipoprotein A [Lp(a)], this study applies Framingham risk score (FRS) and coronary artery calcium (CAC) score to compute a 10\u2010year probability of cardiovascular (CV) events in SS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Case\u2013control study Sixty\u2010three SS\u00a0patients, on a stable hormonal replacement treatment except for growth hormone and 65\u00a0age, body mass index and parity\u2010matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Measurement of serum hsCRP, ApoB and Lp(a) and estimation of CAC with 16\u2010row multislice computed tomography scanner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The concentrations of hsCRP, ApoB\u00a0and Lp(a) were significantly higher in SS patients than in controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). After calculating FRS, 95.2% of SS patients were classified as low risk, 4.8% as intermediate risk and all controls were classified as low risk for probable CV events. CAC was detected in 50.7% SS patients and 7.6% controls (<jats:italic>p<\/jats:italic>\u2009=\u2009.006). According to the CAC score, 26.9% SS patients were classified as at risk (CAC\u2009&gt;\u200910) for incident CV events as against 1.6% controls. The mean Multi\u2010Ethnic Study of Atherosclerosis (MESA) score was significantly higher in patients with SS than controls. CAC corelated significantly with fasting blood glucose (<jats:italic>r<\/jats:italic>\u2009=\u2009.316), ApoB (<jats:italic>r<\/jats:italic>\u2009=\u2009.549), LP(a) (<jats:italic>r<\/jats:italic>\u2009=\u2009.310) and FRS\u00a0(<jats:italic>r<\/jats:italic>\u2009=\u2009.294).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Significant number of asymptomatic SS patients have high coronary artery calcium score and are classified at risk for CAD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14871","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T04:06:25Z","timestamp":1672027585000},"page":"375-382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["High prevalence of coronary artery calcification and increased risk for coronary artery disease in patients with Sheehan syndrome\u2014A case\u2013control study"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5437-2518","authenticated-orcid":false,"given":"Bashir Ahmad","family":"Laway","sequence":"first","affiliation":[{"name":"Department of Endocrinology Sher\u2010I\u2010 Kashmir Institute of Medical Sciences Srinagar Kashmir India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1553-9407","authenticated-orcid":false,"given":"Abid","family":"Rasool","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sher\u2010I\u2010 Kashmir Institute of Medical Sciences Srinagar Kashmir India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Salem","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sher\u2010I\u2010 Kashmir Institute of Medical Sciences Srinagar Kashmir India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raiz 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