{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:50:10Z","timestamp":1791240610382,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Patients with chronic hypoparathyroidism (cHypoPT) are prone to intracranial\u2010calcification, cataract\u00a0and nephrocalcinosis. In this study, we systematically investigated the possibility of increased coronary artery calcification (CAC) and coronary artery disease (CAD) in them.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross\u2010sectional.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Measurements<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010four\u00a0nonsurgical cHypoPT (M:F\u2009=\u200950:44; age\u2009=\u200945\u2009\u00b1\u200915 years) with 18.6\u2009\u00b1\u20099.3 years of illness were assessed. Those with dyspnoea, angina, syncope, abnormal electrocardiogram, echocardiography\u00a0or significant CAC underwent coronary angiography or myocardial\u2010perfusion\u2010stress imaging. Their lipid parameters and\u00a0high\u2010sensitivity C\u2010reactive protein (hsCRP)\u00a0were compared with age\u2010matched healthy controls (Group A,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009101). The prevalence of CAC in cHypoPT was compared with that of subjects referred from cardiology\u2010clinics (Group B,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009148, age\u2009=\u200952\u2009\u00b1\u200911 years).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One of 94 cHypoPT had known CAD. On screening, 17 cHypoPT required evaluation for CAD. Two of 17 had severe coronary stenosis, and 12 showed subclinical\u00a0CAD. CAC and aortic\u2010valve calcification occurred in 21.5% and 11.8%. Clinical and subclinical CAD, CAC\u00a0and aortic\u2010valve calcification in cHypoPT \u226550 years of age was 8.1%, 27.0%, 52.8%\u00a0and 27.8%, respectively. Frequency of age\u2010adjusted CAC was comparable between cHypoPT and control Group B (30.2% vs. 30.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.93). Elevated hsCRP was higher in cHypoPT than in controls A (52% vs. 32%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01). Factors associated with CAD in cHypoPT were CAC and hypertension. However, CAD and CAC showed no association with long\u2010term calcemic or phosphatemic control and intracranial\u2010calcification in cHypoPT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clinical and subclinical CAD was observed in 3.2% and 12.8% of cHypoPT patients. The increased prevalence of CAD, CAC and aortic\u2010valve calcification in cHypoPT above 50 years of age suggested their careful cardiac evaluation during follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.14872","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:44:46Z","timestamp":1672015486000},"page":"505-515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Coronary artery disease and its vascular associates in patients with chronic nonsurgical hypoparathyroidism"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1403-1433","authenticated-orcid":false,"given":"Soma","family":"Saha","sequence":"first","affiliation":[{"name":"Department\u00a0of Endocrinology and Metabolism All India Institute of Medical Sciences New Delhi 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