{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:32:18Z","timestamp":1792715538153,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T00:00:00Z","timestamp":1673136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Minimally invasive parathyroidectomy (MIP) is the standard of care for primary hyperparathyroidism (PHPT). Four dimensional computed tomography(4DCT) and F\u201018 Fluorocholine positron emission tomography\/computed tomography (FCH PET\/CT) localize adenomas accurately to perform MIP. We aimed to conduct a systematic review and metanalysis to evaluate the diagnostic performance of 4DCT and FCH PET\/CT scan for quadrant wise localisation in PHPT patients and to do head\u2010to\u2010head comparison between these two modalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Patients and Measurement\u00a0<\/jats:title><jats:p>After searching through PubMed and EMBASE databases, 46 studies (using histology as a gold standard) of 4DCT and FCH PET\/CT were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total number of patients included were 1651 and 952 for 4DCT scan (studies <jats:italic>n<\/jats:italic>\u2009=\u200926) and FCH PET\/CT scan (studies <jats:italic>n<\/jats:italic>\u2009=\u200924) respectively. In per patient analysis, FCH PET\/CT and 4DCT had pooled sensitivities of 92% (88\u221294) and 85% (73\u221292) respectively and in per lesion analysis, 90% (86\u221293) and 79% (71\u221284), respectively. In the subgroup with negative conventional imaging\/persistent PHPT, FCH PET\/CT had comparable sensitivity to 4DCT (84% [74\u221290] vs. 72% [46\u221288]). As per patient wise analysis, FCH PET\/CT had better detection rates than 4DCT ([92.4 vs. 76.85], odds ratio \u22123.89 [1.6\u22129.36] <jats:italic>p<\/jats:italic>\u2009=\u2009.0024) in the subpopulation where both FCH PET\/CT and 4DCT were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both 4DCT and FCH PET\/CT scan performed well in newly diagnosed patients, patients with persistent disease and in those with inconclusive conventional imaging results. FCH PET\/CT scan had a higher pooled sensitivity than 4DCT in detecting patients with PHPT in head to head comparison.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14875","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T02:26:05Z","timestamp":1672712765000},"page":"262-271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Comparison of 4D computed tomography and F\u201018 fluorocholine PET for localisation of parathyroid lesions in primary hyperparathyroidism: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6556-0234","authenticated-orcid":false,"given":"Dhrumil Deveshkumar","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Radiology Seth G.S. Medical college &amp; King Edward Memorial hospital  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2951-8861","authenticated-orcid":false,"given":"Samiksha","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Post\u2010graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avaneesh Kumar","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Post\u2010graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2304-1361","authenticated-orcid":false,"given":"Chirag Rajkumar","family":"Kopp","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Post\u2010graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9863-7493","authenticated-orcid":false,"given":"Abhiram G.","family":"Ashwathanarayana","sequence":"additional","affiliation":[{"name":"Consultant and head of department of nuclear medicine and PET\/CT Sanjeevani CBCC USA Cancer hospital  Raipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himani Vinayak","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Radiology G.M.E.R.S. Medical college and hospital  Junagadh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7612-506X","authenticated-orcid":false,"given":"Rohit","family":"Barnabas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and metabolism Seth G.S. Medical College &amp; King Edward Memorial hospital  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0410-8778","authenticated-orcid":false,"given":"Sanjay Kumar","family":"Bhadada","sequence":"additional","affiliation":[{"name":"Post\u2010graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6658-0269","authenticated-orcid":false,"given":"Manjunath Havalappa","family":"Dodamani","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and metabolism Seth G.S. 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