{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:18:09Z","timestamp":1789010289877,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T00:00:00Z","timestamp":1675555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Copeptin is secreted in isomolar amounts along with arginine vasopressin peptide (AVP) from the neurohypophysis. Its stability makes it a perfect candidate for the endocrine approach in the diagnosis of AVP\u00a0deficiency (AVPD; cranial diabetes insipidus; CDI). However, pediatric reference values are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Patients<\/jats:title><jats:p>This is a monocentric retrospective analysis of donated residual serum samples from 72 children and adolescents who underwent arginine or growth hormone\u2010releasing hormone\u2010arginine stimulation to test GH secretory capacity from 2018 to 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Copeptin was measured in baseline, 30\u2010, and 60\u2010min samples by BRAHMS Copeptin proAVP Kryptor immunofluorescence assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 72 patients, 4 suffered from complete AVPD (CDI). The baseline level of copeptin in the 68 non\u2010AVPD (non\u2010CDI) patients was highly variable (range: 1.3\u201344.4\u2009pmol\/L). The increase after arginine was moderate (30\u2009min range: 1.6\u201340.4\u2009pmol\/L). The median baseline and peak copeptin levels were 5.6 and 8.0\u2009pmol\/L, respectively. The 2.5th percentile of the baseline and peak values of copeptin were 2.1 and 3.3\u2009pmol\/L, respectively. The increase and peak value of copeptin were inversely related to age (<jats:italic>R<\/jats:italic>\u2009=\u2009\u2212.405; <jats:italic>p<\/jats:italic>\u2009=\u2009.011, and <jats:italic>R<\/jats:italic>\u2009=\u2009\u2212.335; <jats:italic>p<\/jats:italic>\u2009=\u2009.0072, respectively) but not to gender, body mass index\u00a0(standard deviation score) or GH secretion. In the four patients with AVPD (CDI), baseline or stimulated copeptin was below the 2.5th percentile of non\u2010AVPD (non\u2010CDI) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Stimulated copeptin is a promising parameter for the differential diagnosis of polyuria\u2010polydipsia syndrome. However, the low copeptin increase after arginine and the high limit of quantification of the assay are problematic for use in paediatrics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14880","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T06:39:46Z","timestamp":1675060786000},"page":"548-553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Arginine\u2010stimulated copeptin in children and adolescents"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7988-3587","authenticated-orcid":false,"given":"Gerhard","family":"Binder","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology University Children's Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Weber","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology University Children's Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Peter","sequence":"additional","affiliation":[{"name":"Department for Diagnostic Laboratory Medicine, Institute for Clinical Chemistry and Pathobiochemistry University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Schweizer","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology University Children's Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab930"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2012-0092"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505548"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31255-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2005.04.019"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13583"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2011.05.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2016.02.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2011.201"},{"key":"e_1_2_8_11_1","first-page":"1","article-title":"Physical growth of Swiss children from birth to 20 years of age. 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