{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:59:15Z","timestamp":1775091555215,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,11]],"date-time":"2023-06-11T00:00:00Z","timestamp":1686441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Somatostatin analogs are recommended for preoperative therapy in thyrotrophin secreting pituitary adenomas (TSHomas). Octreotide suppression test (OST) was designed to differentiate TSHomas with resistance to thyroid hormones, while its ability to test the sensitivity of SSA has not been fully studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To test the sensitivity of SSA in TSHomas with OST.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>We collected 48 pathologically confirmed TSHoma patients with complete 72\u2009h\u2019 data of OST into analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention<\/jats:title><jats:p>Octreotide suppression test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome<\/jats:title><jats:p>Sensitivity timepoint and cutoff of OST.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the entire OST, the TSH descended maximally 89.07% (73.85%, 96.77%), while the FT3 and FT4 declined slowly [43.40% (37.80%, 54.44%) and 26.59% (19.01%, 33.13%), respectively]. The 24th hour was the timepoint wherein the stability occurs for TSH, and the 48th hour for FT3 and FT4 during OST. In the patients who received both short\u2010 and long\u2010acting somatostatin analogs (SSA), the 24\u2010h timepoint was the most predictive timepoint for the percentage of TSH decline (Spearman's rank correlation analysis, <jats:italic>r<\/jats:italic>\u2009=\u2009.571, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), while the 72\u2010h timepoint was optimal for predicting the magnitude of TSH decline (Spearman's rank correlation analysis, <jats:italic>r<\/jats:italic>\u2009=\u2009.438, <jats:italic>p<\/jats:italic>\u2009=\u2009.005). In the 24th timepoint, a positive correlation was also observed between TSH suppression rate and the percentage decrease and absolute value decrease of FT3 and FT4. Furthermore, in patients treated with long\u2010acting SSA, the 72\u2010h timepoint was optimal for predicting both the percentage (Spearman's rank correlation analysis, <jats:italic>r<\/jats:italic>\u2009=\u2009.587, <jats:italic>p<\/jats:italic>\u2009=\u2009.01) and magnitude (Spearman's rank correlation analysis, <jats:italic>r<\/jats:italic>\u2009=\u2009.474, <jats:italic>p<\/jats:italic>\u2009=\u2009.047) of TSH decline. The 24th hour was the optimal timepoint with 44.54% (50% of median value of TSH in 72\u2010hOST) decrease of TSH being the observing cutoff. The adverse effect of OST was predominantly occurred in the gastrointestinal system and no severe event occurred during OST. Paradoxical response could occur in OST and it did not influence the effect of SSA as long as sensitivity was confirmed. A high level of hormonal control was achieved in the SSA\u2010sensitive patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OST can be used as an efficient tool to guide the adequate use of SSA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14921","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T10:05:51Z","timestamp":1683281151000},"page":"306-314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Characteristics and response cutoff of octreotide suppression test in thyrotrophin (TSH)\u2010secreting pituitary adenomas"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2740-1923","authenticated-orcid":false,"given":"Jie","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamei","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China"},{"name":"Department of Endocrinology, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian","family":"Duan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China"},{"name":"Department of Endocrinology, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Chai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China"},{"name":"Department of Endocrinology, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5172-6870","authenticated-orcid":false,"given":"Huijuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China"},{"name":"Department of Endocrinology, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9571-3705","authenticated-orcid":false,"given":"Kan","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9877-3858","authenticated-orcid":false,"given":"Xiaolan","family":"Lian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China"},{"name":"Department of Endocrinology, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6982-8832","authenticated-orcid":false,"given":"Yong","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.19699"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1810772"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(60)90181-9"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3362"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-21-0162"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-019-01066-x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-014-0611-8"},{"issue":"2","key":"e_1_2_10_10_1","article-title":"The role of somatostatin analog as a first\u2010line therapy in TSH\u2010secreting adenomas. Conference abstract","volume":"37","author":"Feder CKR","year":"2016","journal-title":"Endocr Rev"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04405.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04200.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K06-133"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02192.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0470"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-0863-3"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0041"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-010-0271-2"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-1266"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1988.tb02890.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0470"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126611"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ14-0118"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01360"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-1448"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-1029"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ20-0707"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.4.6548"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1061029"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T14:25:30Z","timestamp":1692282330000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,11]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/cen.14921"],"URL":"https:\/\/doi.org\/10.1111\/cen.14921","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,11]]},"assertion":[{"value":"2023-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}