{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:42:12Z","timestamp":1787164932453,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The prognosis of autoimmune thyroid diseases (AITDs), including Graves' disease (GD) and Hashimoto's disease (HD), varies among patients. B7\u2010H3 and B7\u2010H4, members of the B7 family of proteins, regulate immune response. To clarify the association of B7\u2010H3 and B7\u2010H4 with the pathogenesis and prognosis of AITDs, we examined the expression of the soluble and membrane form of B7\u2010H3 and B7\u2010H4 and genotyped single nucleotide polymorphisms (SNPs) in the\n                      <jats:italic>B7H3<\/jats:italic>\n                      and\n                      <jats:italic>B7H4<\/jats:italic>\n                      genes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We examined the expression of the membrane form of B7\u2010H3 and B7\u2010H4 by flow cytometry and their soluble forms by enzyme\u2010linked immunosorbent assay. We genotyped SNPs in\n                      <jats:italic>B7H3<\/jats:italic>\n                      and\n                      <jats:italic>B7H4<\/jats:italic>\n                      in 187 GD patients, 217 HD patients, and 110 healthy volunteers using the PCR\u2010RFLP method.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The frequency of the\n                      <jats:italic>B7H3<\/jats:italic>\n                      rs3816661 CC genotype was higher in patients with severe HD. G carriers of\n                      <jats:italic>B7H4<\/jats:italic>\n                      rs10754339 A\/G and\n                      <jats:italic>B7H4<\/jats:italic>\n                      rs13505 T\/G were more frequent in patients with AITD. A carrier of\n                      <jats:italic>B7H4<\/jats:italic>\n                      rs10158166 A\/G and C carriers of\n                      <jats:italic>B7H4<\/jats:italic>\n                      rs3806373 C\/T were more frequent in patients with intractable GD. The proportion of B7\u2010H3\n                      <jats:sup>+<\/jats:sup>\n                      monocytes was higher in the CC genotype of\n                      <jats:italic>B7H3<\/jats:italic>\n                      rs3816661 C\/T than in the other genotypes and was lower in patients with GD and HD than in healthy controls. The concentration of soluble B7\u2010H4 was lower in the TG genotype of\n                      <jats:italic>B7H4<\/jats:italic>\n                      rs13505 T\/G than in the TT genotype and was higher in patients with AITD than in healthy controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>B7H3 and B7H4 are associated with AITD susceptibility and prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.14923","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T06:29:21Z","timestamp":1681712961000},"page":"103-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of\n                    <i>B7H3<\/i>\n                    and\n                    <i>B7H4<\/i>\n                    gene polymorphisms and protein expression with the development and prognosis of autoimmune thyroid diseases"],"prefix":"10.1111","volume":"99","author":[{"given":"Haruka","family":"Ozaki","sequence":"first","affiliation":[{"name":"Division of Health Sciences, Department of Clinical Laboratory and Biomedical Sciences Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Inoue","sequence":"additional","affiliation":[{"name":"Division of Health Sciences, Department of Clinical Laboratory and Biomedical Sciences Osaka University Graduate School of Medicine Osaka Japan"},{"name":"Laboratory for Clinical Investigation Osaka University Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Iwatani","sequence":"additional","affiliation":[{"name":"Division of Health Sciences, Department of Clinical Laboratory and Biomedical Sciences Osaka University Graduate School of Medicine Osaka 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