{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T18:45:40Z","timestamp":1780425940598,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000382","name":"Society for Endocrinology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inter\u2010assay variation between different immunoassays and different mass spectrometry methods hampers the biochemical confirmation of male hypogonadism. Furthermore, some laboratories utilise assay manufacturer reference ranges that do not necessarily mirror assay performance characteristics, with the lower limit of normality ranging from 4.9 nmol\/L to 11 nmol\/L. The quality of the normative data underlying commercial immunoassay reference ranges is uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A working group reviewed published evidence and agreed upon standardised reporting guidance to augment total testosterone reports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Evidence\u2010based guidance on appropriate blood sampling, clinical action limits, and other major factors likely to affect the interpretation of results are provided.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This article aims to improve the quality of the interpretation of testosterone results by non\u2010specialist clinicians. It also discusses approaches for assay harmonisation which have been successful in some but not all healthcare systems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.14929","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T22:44:41Z","timestamp":1688251481000},"page":"531-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Standardising the biochemical confirmation of adult male hypogonadism: A joint position statement by the Society for Endocrinology and Association of Clinical Biochemistry and Laboratory Medicine"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2578-8223","authenticated-orcid":false,"given":"Channa N.","family":"Jayasena","sequence":"first","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction Imperial College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipun L.","family":"de Silva","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction Imperial College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9108-9105","authenticated-orcid":false,"given":"Michael W.","family":"O'Reilly","sequence":"additional","affiliation":[{"name":"Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finlay","family":"MacKenzie","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Marrington","sequence":"additional","affiliation":[{"name":"Birmingham Quality (UK NEQAS), University Hospitals NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Royal Hallamshire Hospital, University of Sheffield Medical School Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6878-0769","authenticated-orcid":false,"given":"Mark","family":"Livingston","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Black Country Pathology Services, Walsall Manor Hospital Walsall UK"},{"name":"School of Medicine and Clinical Practice, Faculty of Science and Engineering The University of Wolverhampton Wolverhampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Downie","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Bristol Royal Infirmary Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoff","family":"Hackett","sequence":"additional","affiliation":[{"name":"Department of Urology Spire Hospital Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sud","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry University Hospitals Birmingham NHS Foundation Trust Sutton Coldfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Oxford Centre for Diabetes, Endocrinology and Metabolism Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"David","sequence":"additional","affiliation":[{"name":"Department of Urology Porthcawl Medical Centre, Princess of Wales Hospital Bridgend UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Boot","sequence":"additional","affiliation":[{"name":"Department of Blood Sciences Royal Victoria Infirmary Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayur","family":"Patel","sequence":"additional","affiliation":[{"name":"Great Western Hospital NHS Foundation Trust Swindon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Tarling","sequence":"additional","affiliation":[{"name":"Bedfordshire Hospitals NHS Foundation Trust Bedfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrick","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Division of Endocrinology, Diabetes and Gastroenterology, Faculty of Biology, Medicine and Health University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Quinton","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism Newcastle\u2010upon\u2010Tyne Hospitals NHS Foundation Trust &amp; 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