{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:25:56Z","timestamp":1792301156330,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Insulin resistance and hyperinsulinemia plays an important role in pathogenesis of polycystic ovary syndrome (PCOS). Metformin, Myoinositol and <jats:sc>d<\/jats:sc>\u2010chiro\u2010inositol acts as insulin sensitizers and exerts a beneficial effects in PCOS. The objective is to compare the effect of metformin monotherapy versus a combination of metformin with Myoinositol and <jats:sc>d<\/jats:sc>\u2010chiro\u2010inositol in PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This study is a randomized controlled trial conducted over a period of 6 months. All overweight and obese women with PCOS with the age group between 18 and 35 were included and randomized into two groups, 27 in the metformin monotherapy arm and 26 in the myoinositol combination arm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Measurements<\/jats:title><jats:p>The variables assessed were duration of menstrual cycle, anthropometric parameters, modified Ferriman Gallwey score, global acne score, Fasting insulin, HOMA\u2010IR, fasting lipid profile, serum testosterone, sex hormone binding globulin, luteinizing hormone, follicle stimulating hormone, anti\u2010Mullerian hormone, and pelvic ultrasound to assess ovarian volume, PCOS Questionnaire score. Changes in the parameters from baseline at the end of 6 months of treatment were assessed and compared between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Menstrual cycle regularity improved in both groups with significantly greater improvement in the group receiving myoinositol\u2010based therapy (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Pregnancy rate was equal in both the arms. There was a significant improvement in PCOSQ score in myoinositol\u2010based therapy group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). However, there was no statistically significant difference in other hormonal, metabolic parameters between two groups in spite of symptomatic benefits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The addition of myoinositol to metformin exerts additional benefits in improving menstrual cycle regularity, and quality of life in women with PCOS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14931","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T14:17:26Z","timestamp":1685715446000},"page":"198-205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A randomized controlled trial comparing myoinositol with metformin versus metformin monotherapy in polycystic ovary syndrome"],"prefix":"10.1111","volume":"99","author":[{"given":"Roshan","family":"Nazirudeen","sequence":"first","affiliation":[{"name":"Department of Endocrinology Madurai Medical College &amp; Government Rajaji Hospital  Madurai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5451-0848","authenticated-orcid":false,"given":"Subbiah","family":"Sridhar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Madurai Medical College &amp; Government Rajaji Hospital  Madurai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghavendran","family":"Priyanka","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Madurai Medical College &amp; Government Rajaji Hospital  Madurai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baskaran","family":"Sumathi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Madurai Medical College &amp; Government Rajaji Hospital Madurai Tamil Nadu 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