{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:22:25Z","timestamp":1788218545806,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Primary hyperparathyroidism is a common endocrine disorder, with 80% of all cases usually caused by one single hyperfunctioning parathyroid adenoma. Conventional imaging modalities for the diagnostic work\u2010up of primary hyperparathyroidism (PHPT) include ultrasound of the neck, 99mTc\u2010sestamibi scintigraphy, and four\u2010dimensional computed tomography (4D\u2010CT). However, the role of other imaging modalities, such as 11C\u2010methionine PET\/CT, in the care pathway for PHPT is currently unclear. Here, we report our experience of the diagnostic utility of 11C\u2010methionine PET\/CT in a single\u2010center patient cohort (\n                      <jats:italic>n<\/jats:italic>\n                      = 45).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective single\u2010center cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Measurements<\/jats:title>\n                    <jats:p>The data of eligible patients that underwent 11C\u2010methionine PET\/CT between 2014 and 2022 at Addenbrooke's Hospital (Cambridge, UK) were collected and analyzed. The clinical utility of imaging modalities was determined by comparing the imaging result with histopathological and biochemical outcomes following surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In patients with persistent primary hyperparathyroidism following previous surgery, 11C\u2010methionine PET\/CT identified a candidate lesion in 6 of 10 patients (60.0%), and histologically confirmed in 5 (50.0%). 11C\u2010methionine PET\/CT also correctly identified a parathyroid adenoma in 9 out of 12 patients (75.0%) that failed to be localized on other imaging modalities. 11C\u2010methionine PET\/CT had a sensitivity of 70.0% (95% CI 55.8\u2009\u2013\u200984.2%) for the detection of parathyroid adenomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlights a diagnostic role for 11C\u2010methionine PET\/CT in patients that have undergone unsuccessful prior surgery or have equivocal or negative prior imaging results, aiding localization and a targeted surgical approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.14933","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T14:48:03Z","timestamp":1686149283000},"page":"233-245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Diagnostic utility of\n                    <sup>11<\/sup>\n                    C\u2010methionine PET\/CT in primary hyperparathyroidism in a UK cohort: A single\u2010centre experience and literature review"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7137-1074","authenticated-orcid":false,"given":"Kevin A.","family":"Huynh","sequence":"first","affiliation":[{"name":"Cambridge Endocrine Molecular 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L.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Powlson","sequence":"additional","affiliation":[{"name":"Cambridge Endocrine Molecular Imaging Group, Metabolic Research Laboratories, Wellcome\u2013MRC Institute of Metabolic Science, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Hospital Cambridge Biomedical Campus Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben G.","family":"Challis","sequence":"additional","affiliation":[{"name":"Cambridge Endocrine Molecular Imaging Group, Metabolic Research Laboratories, Wellcome\u2013MRC Institute of Metabolic Science, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's 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