{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:16:31Z","timestamp":1791908191022,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T00:00:00Z","timestamp":1688774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PMP15\/00027"],"award-info":[{"award-number":["PMP15\/00027"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PMP22\/00021"],"award-info":[{"award-number":["PMP22\/00021"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI22\/01364"],"award-info":[{"award-number":["PI22\/01364"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Hyperintensity signal in T2\u2010weighted magnetic resonance imaging (MRI) has been related to better therapeutic response during pasireotide treatment in acromegaly. The aim of the study was to evaluate T2 MRI signal intensity and its relation with pasireotide therapeutic effectiveness in real\u2010life clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Patients and Measurements<\/jats:title><jats:p>Retrospective multicentre study including acromegaly patients treated with pasireotide. Adenoma T2\u2010weighted MRI signal at diagnosis was qualitatively classified as iso\u2010hyperintense or hypointense. Insulin\u2010like growth factor\u00a0(IGF\u2010I), growth hormone\u00a0(GH)\u00a0and tumour volume reduction were assessed after 6 and 12 months of treatment and its effectiveness evaluated according to baseline MRI signal. Hormonal response was considered \u2018complete\u2019\u00a0when normalization of IGF\u2010I levels was achieved. Significant tumour shrinkage was defined as a volume reduction of \u226525% from baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010one patients were included (48% women, 50\u2009\u00b1\u20091.5 years); 93% had previously received somatostatin receptor ligands\u00a0(SRLs) treatment. MRI signal was hypointense in 25 (31%) and hyperintense in 56 (69%) cases. At 12 months of follow\u2010up, 42\/73 cases (58%) showed normalization of IGF\u2010I and 37% both GH and IGF\u2010I. MRI signal intensity was not associated with hormonal control. 19\/51 cases (37%) presented a significant tumour volume shrinkage, 16 (41%) from the hyperintense group\u00a0and 3 (25%) from the hypointense.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>T2\u2010signal hyperintensity was more frequently observed in pasireotide treated patients. Almost 60% of SRLs resistant patients showed a complete normalization of IGF\u2010I after 1 year of pasireotide treatment, regardless of the MRI signal. There was also no difference in the percentage tumour shrinkage over basal residual volume between the two groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14946","type":"journal-article","created":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T10:16:10Z","timestamp":1688811370000},"page":"378-385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Magnetic resonance imaging as a predictor of therapeutic response to pasireotide in acromegaly"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8073-9504","authenticated-orcid":false,"given":"Sabina","family":"Ruiz","sequence":"first","affiliation":[{"name":"Germans Trias i i Pujol Research Institute and Hospital Universitat Aut\u00f2noma de Barcelona Badalona 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