{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T07:28:13Z","timestamp":1751873293470,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The present article analyses pre\u2010operative demographic, biochemical, sonographic and histopathological characteristics of low\u2010risk thyroid neoplasms (LRTNs), with a focus on four subgroups, \u201cwell\u2010differentiated carcinoma\u2010not otherwise specified\u201d (WDC\u2010NOS), \u201cnon\u2010invasive follicular thyroid neoplasm with papillary like nuclear features\u201d (NIFTP), \u201cwell\u2010differentiated tumours of uncertain malignant potential\u201d (WDT\u2010UMP) and \u201cfollicular tumour of uncertain malignant potential\u201d (FT\u2010UMP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study retrospectively analyzed the histopathology of 2453 malignant thyroids and the final analyses included 99 cases diagnosed with LRTNs. The demographic and clinical features, pre\u2010operative thyroid function, ultrasonography results, cytopathology results, histopathology results and prognostic classifications were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The groups were similar demographic characteristics and the majority of clinical data, including comorbidities, thyroid function tests, thyroid cancer\/neck radiotherapy history. NIFTPs represented 69.7% of all LRTNs. All (100%) WDT\u2010UMPs had solitary nodules. Index nodule volume differed among the groups (<jats:italic>p<\/jats:italic>\u2009=\u2009.036), it was the lowest in WDC\u2010NOS [0.68 (0.63\u20130.72 cc)] and highest in FT\u2010UMP [12.6 (0.5\u201364 cc)]. Echogenicity findings were similar. Index nodule TIRADS demonstrated a significant difference (<jats:italic>p<\/jats:italic>\u2009=\u2009.021) but index nodule halo sign and BETHESDA scores were similar in all groups. The diameter, localisation and multicentric structure of LRTNs were again similar for all groups. Finally, prognostic scores suggested similar outcomes in all groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The majority of LRTNs were NIFTPs in our population and all WDT\u2010UMPs were solitary lesions. Index nodule volume was the most essential discriminating sonographic finding but further research must be performed before discriminatory potential can be described.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14965","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T18:03:06Z","timestamp":1694714586000},"page":"502-510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Investigation of pre\u2010operative demographic, biochemical, sonographic and cytopathological findings in low\u2010risk thyroid neoplasms"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8905-3955","authenticated-orcid":false,"given":"Muzaffer Serdar","family":"Deniz","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Faculty of Medicine, Education and Research Hospital Karab\u00fck University Karab\u00fck 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