{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:41:06Z","timestamp":1787614866036,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate both metabolic and hormonal profiles of untreated women with nonclassical congenital adrenal hyperplasia (NCCAH). The secondary objective was to compare above profiles with polycystic ovary syndrome (PCOS) women and healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective, case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Women assigned to one of the groups: (1) NCCAH (<jats:italic>n<\/jats:italic>\u2009=\u2009216), (2) PCOS (<jats:italic>n<\/jats:italic>\u2009=\u2009221), (3) regularly menstruating (<jats:italic>n<\/jats:italic>\u2009=\u2009216).<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Lipid profile including total cholesterol (TC), triglycerides (TG), low\u2010density lipoprotein cholesterol, high\u2010density lipoprotein cholesterol\u00a0along with both fasting glucose (Glu) and insulin (Ins) levels and hormonal parameters were determined among all participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both NCCAH and PCOS women had higher body mass index in comparison to the controls (+7% and 18.9%, respectively). NCCAH women exhibited higher TC (+34.1%) and fasting glucose levels (+18.9%) together with elevated testosterone (60.2%), dehydroepiandrosterone sulphate (28.1%), free androgen index (91.9%) and antim\u00fcllerian hormone (58%) in comparison to healthy controls. PCOS group showed unfavourably altered metabolic profile reflected by higher TC (+35.4%), TG (+25%), fasting Glu (+22%), fasting Ins (+34.4%) along with homoeostatic model assessment for insulin resistance (HOMA\u2010IR; 36.2%) in comparison to the controls. NCCAH women showed both lower insulin (\u221228.5%) and HOMA\u2010IR (\u221231.8%) levels when compared to the PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NCCAH women showed less adversely altered metabolic profile than PCOS women, but not as favourable as in the healthy controls. Optimisation of screening for metabolic and reproductive health may help to initiate the treatment and improve treatment outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14988","type":"journal-article","created":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T01:44:58Z","timestamp":1700876698000},"page":"109-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Nonclassical congenital adrenal hyperplasia: Metabolic and hormonal profile"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1764-0747","authenticated-orcid":false,"given":"Magdalena","family":"Pir\u00f3g","sequence":"first","affiliation":[{"name":"Department of Gynecological Endocrinology Jagiellonian University Medical College Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pulka","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology Jagiellonian University Medical College Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Zabieg\u0142o","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology Jagiellonian University Medical College Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Jach","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology Jagiellonian University Medical College Krakow 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