{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:21:41Z","timestamp":1783488101752,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Insulin\u2010like growth factor 1 (IGF\u20101) measurements play a central role in the diagnosis and follow\u2010up of acromegaly and growth hormone deficiency. However, improving health care outcomes for these patients involves an intricate process of laboratory diagnostics and skilled health care professionals. The integrated effects of IGF\u20101 reports on diagnosis and treatment decisions are yet unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Patients and Measurements<\/jats:title><jats:p>Extended quality assessment, distributing the description of five (real) patient cases with accompanying blood samples. Patients suspected or during follow up for acromegaly or adult onset of growth hormone deficiency were included. Laboratory specialists and endocrinologists in the same centre were asked to interpret their centre\u2010specific IGF\u20101 results by using a laboratory and medical questionnaire. This way, insight could be obtained into the combined effects of different assays, assay harmonisation, reference value sets, and individual physician interpretation in relation to guidelines, thus reviewing the entire diagnostic and management process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Limited variation (CV 13.8\u2009\u00b1\u20092.8) was found in IGF\u20101 concentrations despite different use of the harmonization sample and factor among laboratories. This interlaboratory variation increased upon conversion to SD scores (CV 15.7\u2009\u00b1\u200940.7) as a consequence of the use of different reference value sets. Furthermore, there was a lack of adherence to international guidelines among endocrinologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Highly variable diagnostic and treatment outcomes in acromegaly and AGHD in the Netherlands can be attributed to increased variability of IGF\u20101 upon conversion to SD scores and low adherence to clinical guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.15000","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T09:19:14Z","timestamp":1701681554000},"page":"260-268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["IGF\u20101 as screening tool for acromegaly and adult\u2010onset growth hormone deficiency in the Netherlands"],"prefix":"10.1111","volume":"100","author":[{"given":"Mark R.","family":"Postma","sequence":"first","affiliation":[{"name":"Department of Endocrinology University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 P.","family":"van Beek","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie M.","family":"van der Klauw","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4055-2291","authenticated-orcid":false,"given":"Eef G. W. M.","family":"Lentjes","sequence":"additional","affiliation":[{"name":"Central Diagnostic Laboratory (CDL) University of Utrecht, Utrecht Medical Center Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3457-4179","authenticated-orcid":false,"given":"Anneke C.","family":"Muller Kobold","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2006.053"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2008.349"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2009.02.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.150631"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3059"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2003.203"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-020-09588-z"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1257"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-21-0175"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02836.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13491"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2558"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-020-09594-1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4158\/GL-2019-0405"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2118"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0631"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0179"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0558"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac199"},{"key":"e_1_2_7_21_1","unstructured":"AarsandA Fernandez\u2010CalleP WebsterC et al.\u00a0The EFLM biological variation database.\u00a02021. Accessed October 25 2022.https:\/\/biologicalvariation.eu"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0510"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.15000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T08:45:05Z","timestamp":1707295505000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.15000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,4]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/cen.15000"],"URL":"https:\/\/doi.org\/10.1111\/cen.15000","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,4]]},"assertion":[{"value":"2023-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}