{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:59:32Z","timestamp":1782489572673,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Baseline circulating thrombospondin\u20102 (TSP2) level was identified as a potential novel hepatic fibrosis biomarker that associates with development and progression of hepatic fibrosis in patients with nonalcoholic fatty liver disease and type 2 diabetes. Here, we investigated whether circulating TSP2 levels changed with improvement in liver stiffness (LS), which reflects liver fibrosis on transient elastography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Serum TSP2 levels were measured in participants from a randomized, open\u2010label intervention study, at baseline and after 24\u2010weeks treatment of either dapagliflozin 10\u2009mg (<jats:italic>N<\/jats:italic>\u2009=\u200930) or sitagliptin 100\u2009mg daily (<jats:italic>N<\/jats:italic>\u2009=\u200930). Vibration\u2010controlled transient elastography was performed to evaluate the severity of hepatic fibrosis and steatosis using LS and controlled attenuation parameter (CAP), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Measurements<\/jats:title><jats:p>Among all 60 participants with similar clinical characteristics at baseline (mean HbA1c 8.9%, CAP 289\u2009dB\/m and LS 5.8\u2009kPa), despite similar HbA1c lowering, treatment with dapagliflozin, but not sitagliptin, led to significant improvements in body weight (BW) (<jats:italic>p<\/jats:italic>\u2009=\u2009.012), CAP (<jats:italic>p<\/jats:italic>\u2009=\u2009.015) and LS (<jats:italic>p<\/jats:italic>\u2009=\u2009.011) after 24 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum TSP2 level decreased significantly from baseline in dapagliflozin\u2010treated participants (<jats:italic>p<\/jats:italic>\u2009=\u2009.035), whereas no significant change was observed with sitagliptin. In correlation analysis, change in serum TSP2 levels only positively correlated with change in LS (<jats:italic>r<\/jats:italic>\u2009=\u2009.487, <jats:italic>p<\/jats:italic>\u2009=\u2009.006), but not with changes in BW, CAP or HbA1c after dapagliflozin treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum TSP2 level decreased with LS after dapagliflozin treatment, and was independent of improvements in BW, glycemic control and hepatic steatosis, further supporting the potential of serum TSP2 level as a novel hepatic fibrosis biomarker in type 2 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.15010","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T17:04:32Z","timestamp":1703178272000},"page":"230-237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Serum thrombospondin\u20102 level changes with liver stiffness improvement in 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