{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:14:09Z","timestamp":1769105649189,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effects of simultaneous cortisol cosecretion (CCS) on body composition in computed tomography\u00a0(CT)\u2010imaging and metabolic parameters in patients with primary aldosteronism (PA) with the objective of facilitating early detection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Forty\u2010seven\u00a0patients with PA and CCS confirmed by 1\u2010mg dexamethasone suppression test (DST) with a cutoff of \u22651.8\u2009\u00b5g\/dL were compared with PA patients with excluded CCS\u00a0(non\u2010CCS, <jats:italic>n<\/jats:italic>\u2009=\u200947) matched by age and sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Segmentation of the fat compartments and muscle area at the third lumbar region was performed on non\u2010contrast\u2010enhanced CT images with dedicated segmentation software. Additionally, liver, spleen, pancreas and muscle attenuation were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean cortisol after DST was 1.2\u2009\u00b5g\/dL (33.1\u2009nmol\/L) in the non\u2010CCS group and 3.2\u2009\u00b5g\/dL (88.3\u2009nmol\/L) in the CCS group with mild autonomous cortisol excess (MACE). No difference in total, visceral and subcutaneous fat volumes was observed between the CCS and non\u2010CCS group (<jats:italic>p<\/jats:italic>\u2009=\u2009.7, .6 and .8, respectively). However, a multivariable regression analysis revealed a significant correlation between total serum cholesterol and results of serum cortisol after 1\u2010mg DST (<jats:italic>p<\/jats:italic>\u2009=\u2009.026). Classification of the patients based on visible lesion on CT and PA\u2010lateralization via adrenal venous sampling\u00a0also did not show any significant differences in body composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MACE in PA patients does not translate into body composition changes on CT\u2010imaging. Therefore, early detection of concurrent CCS in PA is currently only attainable through biochemical tests. Further investigation of the long\u2010term clinical adverse effects of MACE in PA is necessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.15013","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T07:52:09Z","timestamp":1704181929000},"page":"212-220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of mild cortisol cosecretion on body composition and metabolic parameters in patients with primary hyperaldosteronism"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3467-1916","authenticated-orcid":false,"given":"Nabeel","family":"Mansour","sequence":"first","affiliation":[{"name":"Department of Radiology University Hospital, LMU Munich Munich 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