{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:58:06Z","timestamp":1769846286296,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Plasma copeptin is a relatively new biomarker for evaluation of arginine vasopressin (AVP)\u00a0secretion. The aim of this study was to test the diagnostic performance of copeptin in patients with polyuria\u2010polydipsia syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Patients and Measurements<\/jats:title><jats:p>This was a prospective study where 88 patients with polyuria\u2010polydipsia syndrome were evaluated with a water deprivation test (WDT).\u00a0Weight, urine osmolality, urine specific gravity, and plasma copeptin were collected at baseline, after 8\u2009h, and at termination of the WDT when one of the following had been reached: (i) &gt;3% weight reduction, (ii) urine specific gravity &gt;1.017 or urine osmolality &gt;600\u2009mOsm\/kg, or (iii) intolerable adverse symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 88 patients (57 women), 21 (24%) were diagnosed with central diabetes insipidus (cDI),\u00a05 (6%) with nephrogenic DI (nDI),\u00a0and 62 (71%) with primary polydipsia (PP).\u00a0Median (interquartile range) copeptin at baseline was 1.7 (1.4\u20132.5) pmol\/L in cDI, 22 (18\u201365) pmol\/L in nDI, and 2.7 (2\u20134) pmol\/L in PP. After 8\u2009h of WDT, the highest copeptin in patients with cDI was 4.0\u2009pmol\/L. In patients with PP: (i) 41 had urine osmolality &lt;600\u2009mOsm\/kg, 7 (17%) of these had copeptin &gt;4.0\u2009pmol\/L, (ii) 21 had urine osmolality \u2265600\u2009mOsm\/kg, 14 (67%) of these had copeptin &gt;4.0\u2009pmol\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Copeptin &gt;4.0\u2009pmol\/L after an overnight WDT can be used to rule out cDI and copeptin \u226521\u2009pmol\/L at baseline to diagnose nDI. The diagnostic performance of copeptin in the context of the WDT is otherwise limited in the diagnostic work\u2010up of patients with polyuria\u2010polydipsia syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.15018","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T05:08:40Z","timestamp":1706677720000},"page":"23-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The diagnostic performance of copeptin in clinical practice: A prospective study"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2288-628X","authenticated-orcid":false,"given":"Penelope","family":"Trimpou","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Endocrinology Sahlgrenska University Hospital Gothenburg 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