{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:24:10Z","timestamp":1785907450296,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The 1\u2010mg overnight dexamethasone suppression test is the most frequently used screening test for Cushing's syndrome. It has been proposed that people with obesity may have insufficient plasma dexamethasone levels for the test which may result in false positives. We sought to compare the plasma dexamethasone levels after 1\u2010mg dexamethasone suppression test in healthy obese participants and in optimal\u2010weight participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 30 optimal\u2010weight participants (BMI\u2009\u2264\u200925\u2009kg\/m<jats:sup>2<\/jats:sup>) and 62 obese participants (BMI\u2009&gt;\u200925\u2009kg\/m<jats:sup>2<\/jats:sup>) were enroled in the study. Obese participants were further divided into class 1 (25\u201329.9\u2009kg\/m<jats:sup>2<\/jats:sup>) and class 2 (&gt;30\u2009kg\/m<jats:sup>2<\/jats:sup>). After a standard overnight 1\u2010mg dexamethasone suppression test, blood samples were obtained for serum cortisol and plasma dexamethasone levels. Plasma dexamethasone levels were quantified using liquid chromatography \u2010 mass spectrometry (LC\u2010MS\/MS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant difference in plasma dexamethasone levels were found between obese and optimal\u2010weight participants (3.31\u2009\u00b1\u20091.35 vs. 2.82\u2009\u00b1\u20091.11 nmol\/L, mean\u2009\u00b1\u2009SD; <jats:italic>p<\/jats:italic>\u2009=\u2009.09 respectively). There were also no correlations found between sex, BMI, body surface area and plasma dexamethasone levels. There was also no significant difference in the proportion of participants who achieved a plasma dexamethasone level &gt;3.3 nmol\/L in comparison between obesity class 1, obesity class 2, and optimal\u2010weight groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that obesity does not affect plasma dexamethasone levels. However, dexamethasone measurement may still be helpful in patients who are being investigated for Cushing's syndrome and suspected to have a false\u2010positive DST.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.15020","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T10:19:01Z","timestamp":1705400341000},"page":"332-337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Assessment of plasma dexamethasone levels after 1\u2010mg dexamethasone suppression test in adults with obesity"],"prefix":"10.1111","volume":"100","author":[{"given":"Pimonrat","family":"Paopongpaiboon","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Chulalongkorn University, and Excellence Center for Diabetes, Hormone, and Metabolism, King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand"},{"name":"Department 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