{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:04:45Z","timestamp":1791439485781,"version":"4.3.3"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Serum luteinising hormone (LH) concentration has been reported to be lower in girls with overweight and obesity (OW\/OB) as compared with girls with normal weight (NW). This study aimed to evaluate peak serum LH concentration during gonadotropin\u2010releasing hormone analogue (GnRHa) test in girls with OW\/OB and NW who had central precocious puberty (CPP) and to determine peak serum LH cut\u2010off for diagnosing CPP in girls with OW\/OB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, Patients and Measurements<\/jats:title>\n                    <jats:p>Medical records of 971 girls with premature breast development who underwent subcutaneous GnRHa (100\u2009\u00b5g\u00a0of triptorelin acetate) test were reviewed. All girls were classified as either CPP or premature thelarche. All of them were further classified into two groups according to their body mass index as NW and OW\/OB groups for each Tanner stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 634 and 337 girls in NW and OW\/OB groups, respectively. CPP was diagnosed in 600 girls (249 had Tanner stage II and 351 had Tanner stage III). There were no differences in peak serum LH concentrations between CPP girls with NW and OW\/OB. Peak serum LH cut\u2010off of 5\u2009IU\/L (the current widely used cut\u2010off) had a sensitivity and a specificity of 75% and 90%, respectively in NW group. Peak serum LH cut\u2010off for CPP diagnosis was lower at 4\u2009IU\/L in the OW\/OB group with greater sensitivity and specificity of 86% and 93%, respectively. The results were reproducible for each Tanner stage of breasts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lower peak serum LH cut\u2010off to 4\u2009IU\/L for diagnosing CPP in girls with OW\/OB should be considered to avoid underdiagnosis of the condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.15026","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T10:54:14Z","timestamp":1706784854000},"page":"368-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Peak serum luteinising hormone cut\u2010off during gonadotropin\u2010releasing hormone analogue test for diagnosing central precocious puberty was lower in girls with obesity as compared with girls with normal weight"],"prefix":"10.1111","volume":"100","author":[{"given":"Natee","family":"Sakornyutthadej","sequence":"first","affiliation":[{"name":"Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5670-2963","authenticated-orcid":false,"given":"Pat","family":"Mahachoklertwattana","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somboon","family":"Wankanit","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6161-6210","authenticated-orcid":false,"given":"Preamrudee","family":"Poomthavorn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0800459"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvab173"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000501336"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304414"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70255-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00380-0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000232164"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14124"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.08.088"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-10-0119"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2108"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0366-6"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3902"},{"key":"e_1_2_9_15_1","first-page":"3979","article-title":"Monosaccharide\u2010induced lipogenesis regulates the human hepatic sex hormone\u2010binding globulin gene","volume":"117","author":"Selva DM","year":"2007","journal-title":"J Clin Invest"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2015.05.001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2005.04.005"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-022-01797-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0720"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.713880"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-20-0651"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21010"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2018.23.4.215"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.3091"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-017-1772-2"},{"key":"e_1_2_9_26_1","volume-title":"National Growth References for Thai Children Aged 5\u201019 Years","author":"Department of Health, Ministry of Public Health","year":"2020"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.44.235.291"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-195909000-00030"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2010.03796.x"},{"key":"e_1_2_9_30_1","unstructured":"Diphereline [package insert]. 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