{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:54:12Z","timestamp":1777294452683,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the metabolic, cardiovascular, and neuropsychological phenotype, quality of life (QoL), and hormonal regulation in individuals with congenital adrenal hyperplasia (CAH),\u00a0a group of autosomal recessive disorders characterized by impaired synthesis of cortisol in the adrenal cortex and, if untreated compensatory hyperandrogenism. CAH is associated with an increased cardiovascular and metabolic morbidity, possibly due to overtreatment with glucocorticoids, leading to weight gain, insulin resistance, and metabolic syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Participants, Measurements<\/jats:title><jats:p>Thirty\u2010seven individuals with CAH and 33 age\u2010 and sex\u2010matched controls were evaluated at a single centre at Aarhus University Hospital with echocardiography, electrocardiogram, 24\u2010h blood pressure, biochemistry, anthropometrics, and autism spectrum, anxiety, depression, personality, cognitive failures, and QoL were assessed using questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CAH individuals had lower height than controls (170.5\u00a0vs. 182.9\u2009cm in males and 160.2\u00a0vs. 170.1\u2009cm in females, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Compared with female controls, females with CAH had higher haemoglobin (8.8\u00a0vs. 8.2\u2009mmol\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.003) and BMI (29.7\u00a0vs. 25.5\u2009kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u20090.006), reduced insulin sensitivity (HOMA\u2010IR):\u00a02.7 vs. 1.9, <jats:italic>p<\/jats:italic>\u2009=\u20090.018), prolonged E\u2010wave deceleration time (193\u00a0vs. 174\u2009cm, <jats:italic>p<\/jats:italic>\u2009=\u20090.015), and E\/\u00e9 ratios (5.4 vs. 4.5, <jats:italic>p<\/jats:italic>\u2009=\u20090.017), and lower self\u2010reported QoL. Males with CAH had more cognitive complaints (<jats:italic>p<\/jats:italic>\u2009=\u20090.034) and higher autistic scores (19.9 vs. 14.9; <jats:italic>p<\/jats:italic>\u2009=\u20090.068)\u00a0compared with male controls. More individuals with CAH than controls reported writing problems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A sex\u2010specific comorbidity profile is evident in CAH, with females presenting with decreased metabolic and overall self\u2010reported health, whereas males with CAH presented with increased cognitive complaints and autistic traits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.15055","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T12:16:55Z","timestamp":1712233015000},"page":"515-526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Endocrine, cardiac and neuropsychological aspects of adult congenital adrenal hyperplasia"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1110-748X","authenticated-orcid":false,"given":"Lukas 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